{"id":7760,"date":"2011-04-12T06:18:47","date_gmt":"2011-04-12T10:18:47","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=7760"},"modified":"2011-07-19T17:44:28","modified_gmt":"2011-07-19T21:44:28","slug":"two-studies-try-to-improve-risk-prediction-for-kidney-disease-progression","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/04\/12\/two-studies-try-to-improve-risk-prediction-for-kidney-disease-progression\/","title":{"rendered":"Two Studies Try to Improve Risk Prediction for Kidney Disease Progression"},"content":{"rendered":"<p>Two papers presented at the World Congress of Nephrology and  simultaneously published online in <em>JAMA<\/em> raise hope for better  tools to calculate the risk for developing kidney failure, but the  techniques are not yet ready for clinical use, according to an  accompanying editorial.<\/p>\n<p>In <a href=\"http:\/\/jama.ama-assn.org\/content\/early\/2011\/04\/05\/jama.2011.468.full\">the  first study, Carmen Peralta and colleagues<\/a> evaluated a  triple-marker strategy combining creatinine, cystatin C, and urine  albumin-to-creatinine ratio (ACR) using data from 26,643 U.S. subjects  enrolled in the REGARDS (Reasons for Geographic and Racial Differences  in Stroke) study. They found that cystatin C and albuminuria &#8220;were both  strongly and independently associated with all-cause death among persons  with or without CKD defined by creatinine-based estimated GFR.&#8221;<\/p>\n<p>In <a href=\"http:\/\/jama.ama-assn.org\/content\/early\/2011\/04\/05\/jama.2011.451.full\">the  second study, Navdeep Tangri and colleagues<\/a> used data from two  Canadian cohorts of patients with CKD to develop and validate a model to  assess the risk for disease progression using routinely measured  variables. The model they developed included age, sex, estimated GFR,  albuminuria, serum calcium, serum phosphate, serum bicarbonate, and  serum albumin and was more accurate than a simpler model in the  validation cohort.<\/p>\n<p>In <a href=\"http:\/\/jama.ama-assn.org\/content\/early\/2011\/04\/05\/jama.2011.502.full\">an  accompanying editorial<\/a>, Marcello Tonelli and Braden Manns say that  neither study should be considered definitive, but &#8220;they provide proof  of concept for 2 new methods that could be used to enhance prognostic  power.&#8221; Both studies, they write, &#8220;are novel and important.&#8221; But the  bigger challenge is to &#8220;demonstrate that using better risk prediction  tools will lead to clinically meaningful benefit for patients.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two papers presented at the World Congress of Nephrology and simultaneously published online in JAMA raise hope for better tools to calculate the risk for developing kidney failure, but the techniques are not yet ready for clinical use, according to an accompanying editorial. In the first study, Carmen Peralta and colleagues evaluated a triple-marker strategy [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[453,799,800,798],"class_list":["post-7760","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-chronic-kidney-disease","tag-creatinine","tag-cystatin-c","tag-risk-prognostication"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/7760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=7760"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/7760\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=7760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=7760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=7760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}