{"id":8046,"date":"2011-04-27T15:48:59","date_gmt":"2011-04-27T19:48:59","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=8046"},"modified":"2011-07-19T17:44:26","modified_gmt":"2011-07-19T21:44:26","slug":"large-meta-analysis-finds-no-link-between-arbs-and-mi-risk","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/04\/27\/large-meta-analysis-finds-no-link-between-arbs-and-mi-risk\/","title":{"rendered":"Large Meta-Analysis Finds No Link Between ARBs and MI Risk"},"content":{"rendered":"<p>Angiotensin-receptor blockers (ARBs) don&#8217;t increase the risk for MI,  according to <a href=\"http:\/\/www.bmj.com\/content\/342\/bmj.d2234\">a large  new meta-analysis published in <em>BMJ<\/em>.<\/a> Concerns about ARBs and MI  have lingered since <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2804%2916451-9\/abstract\">the  VALUE trial in 2004<\/a> found a 19% increase in the risk for MI, though  subsequent trials have not reinforced the finding.<\/p>\n<p>Sripal  Bangalore and colleagues combined data from 37 randomized trials  including more than 147,000 patients and found no increase in MI risk associated with ARBs when compared with controls (relative risk  0.99, CI 0.92-1.07). The authors wrote that the study provides &#8220;firm  evidence to refute the hypothesis that angiotensin receptor blockers  increase the risk of myocardial infarction (ruling out even a 0.3%  absolute increase).&#8221; Increases in death or cardiovascular death were  similarly ruled out. Furthermore, the researchers found that ARBs were  associated with significant reductions in the risks for stroke, heart  failure, and diabetes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Angiotensin-receptor blockers (ARBs) don&#8217;t increase the risk for MI, according to a large new meta-analysis published in BMJ. Concerns about ARBs and MI have lingered since the VALUE trial in 2004 found a 19% increase in the risk for MI, though subsequent trials have not reinforced the finding. Sripal Bangalore and colleagues combined data from [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[230,647],"class_list":["post-8046","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-academic-medicine","tag-arbs"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/8046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=8046"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/8046\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=8046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=8046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=8046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}