{"id":8093,"date":"2011-05-02T17:00:27","date_gmt":"2011-05-02T21:00:27","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=8093"},"modified":"2011-07-19T17:44:26","modified_gmt":"2011-07-19T21:44:26","slug":"standard-guidelines-compared-with-individualized-guidelines","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/05\/02\/standard-guidelines-compared-with-individualized-guidelines\/","title":{"rendered":"Standard Guidelines Compared with Individualized Guidelines"},"content":{"rendered":"<p>Should patients be treated by standard guidelines, or should  guidelines be individualized for patients? In <a href=\"http:\/\/www.annals.org\/content\/154\/9\/627.abstract\">a study published in the<em> Annals of Internal Medicine<\/em><\/a>, David Eddy and colleagues used data  from the Atherosclerosis Risk in Communities (ARIC) Study to calculate  and compare the expected benefit from hypertension treatment based on  JNC 7 guidelines with the expected benefit from treatment based on individualized guidelines. (Individualized guidelines were derived  from a calculator developed as part of the <a href=\"http:\/\/cardiobrief.org\/2009\/12\/10\/wired-david-eddys-efforts-to-replace-human-trials-with-computer-models\/\">Archimedes computer model<\/a> designed to simulate clinical trials.)<\/p>\n<p>The  authors (all of whom are affiliated with the Archimedes project) found  that &#8220;individualized guidelines could prevent more than an additional  43% of MIs and strokes than JNC 7 guidelines for the same cost.&#8221; To  achieve the same benefit as the JNC 7 guidelines, 52% of people  indicated for treatment by JNC 7 would not be indicated for treatment by  the individualized guidelines, while 36% of people indicated for  treatment by the individualized guidelines would not be indicated for  treatment by JNC 7.<\/p>\n<p>The authors conclude: &#8220;Our results show that  individualized guidelines can prevent the same number of MIs and strokes  at a lower cost (and by exposing fewer people to the risks and adverse  effects of treatments) or can prevent more MIs and strokes at the same  cost as the JNC 7 guideline.&#8221;<\/p>\n<p>In <a href=\"http:\/\/www.annals.org\/content\/154\/9\/638.extract\">an accompanying editorial<\/a>,  Douglas Owens notes that &#8220;tailoring recommendations is easier said than  done.&#8221; He writes that &#8220;tailored recommendations must meet 3 challenges&#8221;  before being generally accepted. First, for a specific clinical  problem, individualized guidelines must be shown to have the potential  to produce better results. Second, clinical trials must demonstrate  these potential benefits. Third, the individualized guidelines must be  &#8220;easy enough to use that clinicians will adopt them.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Should patients be treated by standard guidelines, or should guidelines be individualized for patients? In a study published in the Annals of Internal Medicine, David Eddy and colleagues used data from the Atherosclerosis Risk in Communities (ARIC) Study to calculate and compare the expected benefit from hypertension treatment based on JNC 7 guidelines with the [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[824,823,595,454],"class_list":["post-8093","post","type-post","status-publish","format-standard","hentry","category-prevention","tag-archimedes","tag-computer-models","tag-guidelines","tag-hypertension"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/8093","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=8093"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/8093\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=8093"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=8093"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=8093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}