{"id":8526,"date":"2011-06-02T15:40:05","date_gmt":"2011-06-02T19:40:05","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=8526"},"modified":"2011-07-19T17:44:24","modified_gmt":"2011-07-19T21:44:24","slug":"small-study-suggests-possible-benefits-of-fish-oil-supplements-for-pci-patients","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/06\/02\/small-study-suggests-possible-benefits-of-fish-oil-supplements-for-pci-patients\/","title":{"rendered":"Small Study Suggests Possible Benefits of Fish-Oil Supplements for PCI Patients"},"content":{"rendered":"<p>A small study from Poland raises the possibility that supplements containing omega-3 fatty acids may have beneficial effects when given to PCI patients already taking aspirin and clopidogrel. The investigator-initiated study randomized 54 PCI patients to either 1 g per day of n-3 PUFA daily or placebo for one month. <a href=\"http:\/\/atvb.ahajournals.org\/cgi\/content\/abstract\/ATVBAHA.111.228593v1\">The results have been published in <em>Arteriosclerosis, Thrombosis, and Vascular Biology<\/em><\/a>.<\/p>\n<p>After one month, treatment with n-3-PUFA compared with placebo resulted in:<\/p>\n<ul>\n<li>significantly larger pores in the fibrin network, suggesting increased susceptibility to fibrinolysis,<\/li>\n<li> a reduction in thrombin generation, and<\/li>\n<li>a reduction in oxidative stress.<\/li>\n<\/ul>\n<p>The supplements had no significant effect on fibrinogen or clotting-factor levels.<a href=\"http:\/\/content.onlinejacc.org\/cgi\/content\/abstract\/55\/16\/1671\"> A previous paper from the same study published last year in <em>JACC<\/em><\/a> reported that the fish-oil supplement helped augment the response of platelets to clopidogrel.<\/p>\n<p>\u201cThere are no other studies on omega-3 effects in patients who were already being treated with optimal medical therapy after stent placement,\u201d said the first author of the study, Grzegorz Gajos, in an <a href=\"http:\/\/www.newsroom.heart.org\/index.php?s=43&amp;item=1346\">AHA press release<\/a>. \u201cThis was a proof of concept study. We were looking for any effect and what it might be.\u201d<\/p>\n<p>The authors concluded that their results indicate &#8220;novel antithrombotic effects produced by these agents. These effects may contribute to a decreased risk of thrombotic events after PCI following n-3 PUFA administration. A larger study is needed to assess clinical benefits potentially related to these novel antithrombotic effects of n-3 PUFA.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A small study from Poland raises the possibility that supplements containing omega-3 fatty acids may have beneficial effects when given to PCI patients already taking aspirin and clopidogrel. The investigator-initiated study randomized 54 PCI patients to either 1 g per day of n-3 PUFA daily or placebo for one month. The results have been published [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[334,861,559,558,301],"class_list":["post-8526","post","type-post","status-publish","format-standard","hentry","category-interventional-cardiology","tag-clopidogrel","tag-dual-antiplatelet-therapy","tag-fish-oils","tag-omega-3","tag-pci"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/8526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=8526"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/8526\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=8526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=8526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=8526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}