{"id":1108,"date":"2010-10-01T17:26:01","date_gmt":"2010-10-01T21:26:01","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=1108"},"modified":"2015-06-04T15:24:36","modified_gmt":"2015-06-04T19:24:36","slug":"five-friday-fasciolas","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/five-friday-fasciolas\/2010\/10\/01\/","title":{"rendered":"Five Friday Fasciolas"},"content":{"rendered":"

\"watercress_salad\"As we await either the start of the baseball playoffs (or Spring Training<\/a>), here is some ID\/HIV content to consider, in no particular order:<\/p>\n

    \n
  1. Could adenovirus infection be the cause of obesity?\u00a0 That would be the media take, especially from this highly-esteemed research journal, The New York Daily News<\/a>. (Warning:\u00a0 kind of ugly photo in link.)\u00a0 But if you read the actual paper<\/a>, the scientists appropriately\u00a0note that the study just demonstrated an association with childhood obesity, not causation.\u00a0 Still — did you know that animal models show that adenovirus 36 infection increases body fat?\u00a0 I did not.<\/li>\n
  2. Remember ceftobiprole?\u00a0 The “Fifth Generation” anti-MRSA cephalosporin approved for use in Europe, Canada, Hong Kong, etc and heading to the USA?\u00a0Well you can take Canada<\/a>,\u00a0Switzerland<\/a> and soon several other countries (Russia, Ukraine and Azerbaijan) off that list, as the drug is being pulled due to concerns raised by the FDA<\/a> in their review.\u00a0 By contrast, it does look\u00a0like ceftaroline (reminds me of Caroline<\/a>,\u00a0less so\u00a0Carolyn<\/a>) is on the way. My reason for optimism this time is the uninimously favorable\u00a0vote<\/a> from\u00a0an FDA Advisory Committee meeting; here are the slides<\/a> from the meeting last month.<\/li>\n
  3. This MMWR paper<\/a> on the prevalence of HIV among gay men in the USA got lots of attention, and appropriately so.\u00a0 The reason?\u00a0 “New CDC analysis finds 1 in 5 gay and bisexual men in a study of 21 major U.S. cities is infected with HIV, and nearly half (44 percent) are unaware; young men and men of color are least likely to know their status.” <\/em>Important take-home message:\u00a0 In the effort to\u00a0expand general HIV screening strategies, we can’t forget that there’s a critical role for targeted testing as well.\u00a0\u00a0 Some would argue this is more<\/em> important.<\/li>\n
  4. One of the most widely-cited papers in all of HIV medicine in the late 1990s\/early 2000s\u00a0was this one<\/a>, which showed that you needed to take 95% of HIV medications\u00a0for the best shot at \u00a0suppressing the virus.\u00a0 (I must have some fifty copies of this study in various slide sets scattered around my hard drive.)\u00a0 We’ve known for some time that the adherence bar isn’t set this high\u00a0with today’s better regimens, but\u00a0could one ever imagine that\u00a0someone could take as little as\u00a040%<\/a> of their meds without much risk of viral rebound, provided it’s been preceded by long term virologic suppression?\u00a0\u00a0 Not that I’m suggesting this as an actual strategy, but this should be quite reassuring for our successfully treated patients who think they can never miss a dose.<\/em><\/li>\n
  5. Easily one of the un-funniest pranks<\/a> I’ve heard about, maybe ever. Oh, what will kids think of next.<\/li>\n<\/ol>\n

    Enjoy your watercress salad<\/a>!<\/p>\n","protected":false},"excerpt":{"rendered":"

    As we await either the start of the baseball playoffs (or Spring Training), here is some ID\/HIV content to consider, in no particular order: Could adenovirus infection be the cause of obesity?\u00a0 That would be the media take, especially from this highly-esteemed research journal, The New York Daily News. (Warning:\u00a0 kind of ugly photo in […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,5,8],"tags":[],"class_list":["post-1108","post","type-post","status-publish","format-standard","hentry","category-hiv","category-infectious-diseases","category-patient-care"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=1108"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1108\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=1108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=1108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=1108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}