{"id":1149,"date":"2010-10-29T16:09:02","date_gmt":"2010-10-29T20:09:02","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=1149"},"modified":"2015-06-04T15:24:30","modified_gmt":"2015-06-04T19:24:30","slug":"with-hiv-medication-adherence-rates-its-not-a-competition","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/with-hiv-medication-adherence-rates-its-not-a-competition\/2010\/10\/29\/","title":{"rendered":"With HIV Medication Adherence, It’s Not a Competition"},"content":{"rendered":"

\"pieThere has been an irresistable\u00a0urge for people — doctors, public health officers, politicians, journalists, the usual pundits — to compare adherence to HIV treatment in resource-rich vs. resource-limited setting.\u00a0<\/p>\n

I suspect\u00a0this is because\u00a0the whole issue got off to a famously bad start in 2001, when then-head of \u00a0the U.S. Agency for International Development (USAID) Andrew Natsios said in an interview with the Boston Globe<\/em><\/a> that Africans:<\/p>\n

… don’t know what Western time is. You have to take these (AIDS) drugs a certain number of hours each day, or they don’t work. Many people in Africa have never seen a clock or a watch their entire lives. And if you say, one o’clock in the afternoon, they do not know what you are talking about. They know morning, they know noon, they know evening, they know the darkness at night.<\/p><\/blockquote>\n

Yikes.\u00a0<\/p>\n

The reality, of course, is that patients in Africa and other resource-limited settings have been just as adherent to HIV treatment as people in developed countries.\u00a0<\/p>\n

But are they more<\/em> adherent?<\/p>\n

Yes, says this article in the New York Times<\/em><\/a>.\u00a0 And yes again, says this\u00a0widely-quoted meta-analysis<\/a>, published in JAMA<\/em> in 2006.\u00a0<\/p>\n

But I don’t buy it — never have.\u00a0\u00a0<\/p>\n

In fact, in\u00a0his otherwise inspiring talks on how to bring lifesaving health care to poor countries, my doppelganger Paul Farmer<\/a> has a small section\u00a0I absolutely hate.\u00a0 (Am I allowed to criticize Paul Farmer?\u00a0 Sure — he knows it.)\u00a0 It’s where he compares adherence rates for Haitians in his community-based programs to that of patients discharged from the inpatient medical service at Grady Memorial Hospital in Atlanta.\u00a0<\/p>\n

Not surprisingly, the Haitians do better.\u00a0 But that’s not really a fair comparison, because in Haiti the people on treatment are actively seeking care, while with these particular patients at\u00a0Grady, they are actively running away from it until they get so sick they need to be hospitalized.\u00a0<\/p>\n

At the great risk of oversimplifying the issue — and acknowledging up front that I do my work exclusively here in the USA (but in a setting with a very broad range of patients) — here’s my take:<\/p>\n

    \n
  1. Most people with HIV — everywhere — are phenomenally adherent to therapy.<\/strong>\u00a0 Not only that, it gets better over time.<\/a>\u00a0\u00a0Excellent adherence\u00a0is especially common in those\u00a0who, as mentioned above, are seeking care rather than trying to evade it.\u00a0Remember the AZT-every-4-hours group?\u00a0 The indinavir-every-8-hours-on-an-empty-stomach group?\u00a0 With today’s easier regimens, lots<\/em> of patients barely ever skip a dose, and they look at you like you’re crazy when you ask them how often they miss.\u00a0 And Carlos del Rio tells me that many of them are receiving care\u00a0right near Grady at the outstanding Ponce de Leon Center.<\/a><\/li>\n
  2. It is\u00a0incorrect\u00a0to think that this ability to take medications differs in different countries.<\/strong>\u00a0 In the same way that Natsios got it wrong about Africa, it’s wrong to assume that we can’t do it here based on antiquated data, examination of only a\u00a0selected subset of patients, or reverse cultural assumptions.\u00a0 I heard someone once say at a lecture that adherence was worse in the United States than in\u00a0Kenya because US HIV patients “take everything for granted.”\u00a0 Yikes again.<\/li>\n
  3. The huge benefits of HIV therapy notwithstanding, some people just don’t get it, and they drive us crazy.<\/strong>\u00a0 Everyone knows a small group of patients — see pie graph above, as my unscientific estimate puts it at 5-15% — who just won’t play the ART game by the rules, or at least won’t do it consistently.\u00a0 They are in denial; or they don’t really believe you that HIV is lethal; or they have side effects to everything; or their life is in total chaos; or they have psychiatric illness; or they have drug or alcohol problems.\u00a0 Or all of the above.\u00a0 And you know what?\u00a0 Though small in number,\u00a0such people are everywhere (even in Africa<\/a>),\u00a0and found with every disease.\u00a0 They occupy a tremendous amount of our clinical energies and a disproportionate share of resources — and not surprisingly, it’s this group that gets hospitalized repeatedly at Grady, as well as every other hospital that sees its fair share of HIV patients.<\/li>\n<\/ol>\n

    So the next time you hear someone make a broad generalization about adherence being better in City A vs B, or Country X vs Y, remind them that people are people — and adherence to HIV therapy is likely to be the same everywhere.\u00a0<\/p>\n

    That is, excellent until proven otherwise.<\/p>\n","protected":false},"excerpt":{"rendered":"

    There has been an irresistable\u00a0urge for people — doctors, public health officers, politicians, journalists, the usual pundits — to compare adherence to HIV treatment in resource-rich vs. resource-limited setting.\u00a0 I suspect\u00a0this is because\u00a0the whole issue got off to a famously bad start in 2001, when then-head of \u00a0the U.S. Agency for International Development (USAID) Andrew […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,8,9],"tags":[39,423,701],"class_list":["post-1149","post","type-post","status-publish","format-standard","hentry","category-hiv","category-patient-care","category-policy","tag-adherence","tag-hiv","tag-paul-farmer"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=1149"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1149\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=1149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=1149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=1149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}