{"id":1338,"date":"2011-01-20T21:17:57","date_gmt":"2011-01-21T02:17:57","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=1338"},"modified":"2015-06-04T15:24:06","modified_gmt":"2015-06-04T19:24:06","slug":"a-new-antiretroviral-drug-class-and-a-movie","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/a-new-antiretroviral-drug-class-and-a-movie\/2011\/01\/20\/","title":{"rendered":"A New Antiretroviral Drug Class, and a Movie"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2011\/01\/Day_the_Earth_Stood_Still_19511.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-1340\" title=\"Day_the_Earth_Stood_Still_1951\" src=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2011\/01\/Day_the_Earth_Stood_Still_19511.jpg\" alt=\"\" width=\"154\" height=\"224\" \/><\/a>In my email in-box today was a very odd press release,\u00a0referring to\u00a0<a href=\"http:\/\/www.plosone.org\/article\/info:doi\/10.1371\/journal.pone.0015135\" target=\"_blank\">this paper<\/a>, just published in PLoS ONE. \u00a0With the subject line, &#8220;Koronis &#8211; Clinical Trial Results Demonstrate Promise for First Non-suppressive HIV Drug,&#8221; it included the following information:<\/p>\n<p style=\"padding-left: 30px\">Recently published Phase 2a clinical trial results show that the frequency of specific, drug-induced mutations in the HIV genome can be significantly increased by administering KP-1461, a drug being developed by Koronis Pharmaceuticals based on its novel <strong>Viral Decay Acceleration<\/strong> (VDA) drug mechanism. Koronis is planning a follow-on Phase 2 trial to determine the treatment duration required to achieve a clinically meaningful decrease in a patient\u2019s viral load.<\/p>\n<p>First, you don&#8217;t want to be known as a &#8220;Non-suppressive HIV drug.&#8221; \u00a0And second, while I get the premise that giving a drug that leads to mutations probably indicates some sort of selection pressure, it&#8217;s a long way from this observation to an actual antiviral agent.<\/p>\n<p>But who knows? \u00a0This may be the next great antiviral drug class, and the phrase <strong>&#8220;Viral Decay Acceleration&#8221;<\/strong> &#8212; with its faint echo of <a href=\"http:\/\/www.filmsite.org\/sci-fifilms2.html\" target=\"_blank\">1950s sci-fi movies<\/a> &#8212; sounds incredibly cool. \u00a0According to the company&#8217;s <a href=\"http:\/\/www.koronispharma.com\/\" target=\"_blank\">web site<\/a>, VDA &#8220;exploits the strength of a virus \u2013 its high mutation rate \u2013 to target its collapse.&#8221;<\/p>\n<p>So dim the lights, grab some popcorn, and watch the movie <a href=\"http:\/\/www.youtube.com\/watch?v=3FPuIMycqv4\" target=\"_blank\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In my email in-box today was a very odd press release,\u00a0referring to\u00a0this paper, just published in PLoS ONE. \u00a0With the subject line, &#8220;Koronis &#8211; Clinical Trial Results Demonstrate Promise for First Non-suppressive HIV Drug,&#8221; it included the following information: Recently published Phase 2a clinical trial results show that the frequency of specific, drug-induced mutations in [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,5,10],"tags":[77,79,423,542],"class_list":["post-1338","post","type-post","status-publish","format-standard","hentry","category-hiv","category-infectious-diseases","category-research","tag-antiretroviral-therapy","tag-antiviral","tag-hiv","tag-koronis"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=1338"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1338\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=1338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=1338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=1338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}