{"id":1880,"date":"2011-08-31T09:23:16","date_gmt":"2011-08-31T13:23:16","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=1880"},"modified":"2015-06-04T15:15:51","modified_gmt":"2015-06-04T19:15:51","slug":"its-time-for-antibiotic-placebos","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/its-time-for-antibiotic-placebos\/2011\/08\/31\/","title":{"rendered":"It’s Time for Antibiotic Placebos"},"content":{"rendered":"

\"\"<\/a>As I’m sure you all agree, it’s high time we had a good antibiotic placebo.<\/p>\n

Just think — we’d be able to prescribe a 100% effective treatment for viral respiratory tract infections, with the assurance of no risk of antibiotic resistance, C diff, allergic reactions, tendon ruptures, photosensitivity, drug-drug interactions, or any of the myriad other side effects that real antibiotics have.<\/p>\n

Plus, based on studies like this one<\/a>, we could even tell our patients that they’re receiving an antibiotic placebo, and they’d still get better. There, ethical quandaries of placebo prescribing solved.<\/p>\n

What inspired this thought on antibiotic placebos was this email exchange:<\/p>\n

Hi Paul,
\nOur primary care group would love to have you come give an update on antibiotics during our Friday conference. Am cc’ing Chuck our practice director to make sure he agrees with the topic. There’s a lot of variability in antibiotic prescribing within our group, hoping you can enlighten us.
\nThanks,
\nNora<\/p><\/blockquote>\n

So Chuck chimed in:<\/p>\n

Sounds great. \u00a0But Nora, what do you mean “variability in antibiotic prescribing” if everyone gets azithro?
\nChuck<\/p><\/blockquote>\n

Now it hardly bears mentioning that Chuck is one of the funniest doctors I know, and that he was being facetious.<\/p>\n

But just think how much macrolide resistance we could avoid if, instead of a “Z-pack”, we had an “S-pack” (“S” for sucrose). That’s 6 pills (two on the first day, then one a day for 4 additional days), with the promise that it will be just as effective as azithromycin.<\/p>\n

And if you don’t believe me, read this paper in The Lancet<\/a><\/em> for proof (figure from paper in above image). And this news article in The Onion<\/a><\/em> for more information.<\/p>\n

Sucramycin (brand name Sucracil\u00ae), anyone?<\/p>\n","protected":false},"excerpt":{"rendered":"

As I’m sure you all agree, it’s high time we had a good antibiotic placebo. Just think — we’d be able to prescribe a 100% effective treatment for viral respiratory tract infections, with the assurance of no risk of antibiotic resistance, C diff, allergic reactions, tendon ruptures, photosensitivity, drug-drug interactions, or any of the myriad […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,5,8],"tags":[72,95,194,727],"class_list":["post-1880","post","type-post","status-publish","format-standard","hentry","category-health-care","category-infectious-diseases","category-patient-care","tag-antibiotics","tag-azithromycin","tag-clinical-research","tag-placebo"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=1880"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/1880\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=1880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=1880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=1880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}