{"id":2054,"date":"2011-10-29T08:31:45","date_gmt":"2011-10-29T12:31:45","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=2054"},"modified":"2015-06-04T15:15:35","modified_gmt":"2015-06-04T19:15:35","slug":"will-an-antiretroviral-patch-help-adherence-doubtful","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/will-an-antiretroviral-patch-help-adherence-doubtful\/2011\/10\/29\/","title":{"rendered":"Will An Antiretroviral Patch Help Adherence? Doubtful &#8230;"},"content":{"rendered":"<p>This <a href=\"http:\/\/www.womenshealth.gov\/news\/headlines\/658185.cfm\" target=\"_blank\">little nugget<\/a> came up recently, found by our\u00a0<em><a href=\"http:\/\/aids-clinical-care.jwatch.org\/\" target=\"_blank\">Journal Watch<\/a><\/em> Executive Editor:<\/p>\n<blockquote><p>Preliminary research suggests that a patch could deliver an AIDS drug to patients &#8230; The researchers successfully used transdermal patches to administer 96 percent of an AIDS drug to simulated skin over a week. &#8220;Still, the important limitation of pills, regardless of how few there are or even how minimal the side effects, is adherence,&#8221; Johnston [the investigator] noted. Research has shown that many patients, if not most, don&#8217;t take their pills all the time.<\/p><\/blockquote>\n<p><a href=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2011\/10\/patches1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-2056\" title=\"patches\" src=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2011\/10\/patches1.jpg\" alt=\"\" width=\"250\" height=\"250\" \/><\/a>Setting aside for a moment the fact that <a href=\"http:\/\/cid.oxfordjournals.org\/content\/early\/2011\/08\/12\/cid.cir467.abstract\" target=\"_blank\">most patients actually do take their medications just fine,<\/a> thank you &#8212; and that this particular transdermal HIV drug delivery system hasn&#8217;t even been tested on animals, let alone humans &#8212; I have always wondered about the assumption that novel drug delivery systems would improve adherence.<\/p>\n<p>Seems to me that the major problem with non-adherent patients isn&#8217;t that they <em>can&#8217;t<\/em> take pills.<\/p>\n<p>It&#8217;s that they <em>won&#8217;t<\/em> take them.<\/p>\n<p>And I strongly suspect that most would make the same choice when it comes to putting on a patch every day (or even every week).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This little nugget came up recently, found by our\u00a0Journal Watch Executive Editor: Preliminary research suggests that a patch could deliver an AIDS drug to patients &#8230; The researchers successfully used transdermal patches to administer 96 percent of an AIDS drug to simulated skin over a week. &#8220;Still, the important limitation of pills, regardless of how [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,8,10],"tags":[77,289,423],"class_list":["post-2054","post","type-post","status-publish","format-standard","hentry","category-hiv","category-patient-care","category-research","tag-antiretroviral-therapy","tag-drug-delivery-systems","tag-hiv"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=2054"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2054\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=2054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=2054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=2054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}