{"id":2158,"date":"2011-11-28T11:27:19","date_gmt":"2011-11-28T16:27:19","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=2158"},"modified":"2011-11-28T11:27:19","modified_gmt":"2011-11-28T16:27:19","slug":"tenofovir-gel-disappointing-in-voice-trial","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/tenofovir-gel-disappointing-in-voice-trial\/2011\/11\/28\/","title":{"rendered":"Tenofovir Gel Disappointing in VOICE Trial"},"content":{"rendered":"<p>From the <a href=\"http:\/\/www.mtnstopshiv.org\/node\/3909\" target=\"_blank\">Microbicide Trials Network<\/a>:<\/p>\n<blockquote><p>VOICE, an HIV prevention trial that has been evaluating two antiretroviral (ARV)-based approaches for preventing the sexual transmission of HIV in women \u2013 daily use of one of two different ARV tablets or of a vaginal gel \u2013 will be dropping the vaginal gel from the study &#8230; The DSMB recommended that VOICE discontinue the tenofovir gel and placebo gel arms, because there was no difference in effect between them in preventing HIV infection.<\/p><\/blockquote>\n<p>This leaves only the TDF\/FTC intervention arm still open in VOICE, as the TDF alone arm was stopped for futility by a\u00a0<a href=\"http:\/\/www.mtnstopshiv.org\/node\/3622\" target=\"_blank\">similar DSMB action in September<\/a>.<\/p>\n<p>We&#8217;ll be covering these new data in greater detail in <em><a href=\"http:\/\/aids-clinical-care.jwatch.org\/cgi\/content\/full\/2011\/1205\/1\">Journal Watch AIDS Clinical Care<\/a> <\/em>(including some speculation on why tenofovir gel here failed), but on first pass, this news comes as a big disappointment &#8212; especially in light of the <a href=\"http:\/\/aids-clinical-care.jwatch.org\/cgi\/content\/full\/2010\/726\/1\" target=\"_blank\">CAPRISA 004 <\/a>study, results of which triggered a standing ovation at the International AIDS Conference in Vienna in 2010.<\/p>\n<p>In fact, HIV prevention research has been on quite a roll the past few years, so much so that maybe we&#8217;re unrealistically expecting the data equivalent of a home run with each study.<\/p>\n<p>If it were that easy, however, we wouldn&#8217;t have to do the research &#8212; in other words (to continue the metaphor), <a href=\"http:\/\/bleacherreport.com\/articles\/657727-mlb-this-is-why-they-play-the-game-major-league-baseball-cant-be-predicted\" target=\"_blank\">that&#8217;s why they play the games on the field.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From the Microbicide Trials Network: VOICE, an HIV prevention trial that has been evaluating two antiretroviral (ARV)-based approaches for preventing the sexual transmission of HIV in women \u2013 daily use of one of two different ARV tablets or of a vaginal gel \u2013 will be dropping the vaginal gel from the study &#8230; The DSMB [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,10],"tags":[423,750,908,982],"class_list":["post-2158","post","type-post","status-publish","format-standard","hentry","category-hiv","category-research","tag-hiv","tag-prevention","tag-tenofovir","tag-voice"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=2158"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2158\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=2158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=2158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=2158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}