{"id":2485,"date":"2012-02-23T05:42:48","date_gmt":"2012-02-23T10:42:48","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=2485"},"modified":"2015-06-04T15:14:58","modified_gmt":"2015-06-04T19:14:58","slug":"hcv-and-the-retooling-of-hivid-specialists","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/hcv-and-the-retooling-of-hivid-specialists\/2012\/02\/23\/","title":{"rendered":"Hepatitis C and the &#8220;Retooling&#8221; of HIV\/ID Specialists"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2012\/02\/6355978_blog1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-2492\" title=\"C\" src=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2012\/02\/6355978_blog1.jpg\" alt=\"\" width=\"320\" height=\"286\" \/><\/a>The news that hepatitis C (HCV) has passed HIV as a cause of death in the United States got quite a bit of attention when it was first presented last year at ICAAC &#8212; and no doubt the published paper, in this week&#8217;s <a href=\"http:\/\/www.annals.org\/content\/156\/4\/271.abstract\" target=\"_blank\"><em> Annals of Internal Medicine<\/em><\/a>,\u00a0will also cause a stir.<\/p>\n<p>In fact, I boldly predict that going forward, (approximately) 94.2% of HCV-related research grants, journal articles, and lay press articles will cite this paper, making it (for now) the <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM199803263381301\" target=\"_blank\"><em>&#8220;Palella NEJM 1998&#8221;<\/em><\/a> of HCV.<\/p>\n<p>(For those of you who don&#8217;t know <em>Palella NEJM 1998<\/em>, this was the first paper in a major medical journal to demonstrate the dramatic decline in HIV-related mortality due to effective HIV therapy.\u00a0<a href=\"http:\/\/www.nejm.org\/action\/showImage?doi=10.1056%2FNEJM199803263381301&amp;iid=f01\" target=\"_blank\">Figure 1<\/a> from that study is permanently emblazoned on HIV specialists&#8217; retinas.)<\/p>\n<p>But the <em>Annals <\/em>paper also reminded me &#8212; again &#8212;\u00a0that there&#8217;s a significant retooling going on in the HIV\/ID field to accommodate HCV. And for some docs and HIV organizations, it&#8217;s more than a retooling &#8212; it&#8217;s practically a comprehensive overhaul. What do I mean exactly? Some citations, some anecdotes:<\/p>\n<ul>\n<li>The International AIDS Society &#8211; USA is now officially known as the <a href=\"http:\/\/www.iasusa.org\/\" target=\"_blank\">&#8220;International <strong>Antiviral <\/strong>Society &#8211; USA&#8221;<\/a> and has HCV therapy as a major focus of its efforts.<\/li>\n<li>Two large HIV annual educational meetings &#8212; one led by <a href=\"http:\/\/www.clinicaloptions.com\/HIV\/Live%20Events\/Symposium\/2012%20Annual%20Update.aspx\" target=\"_blank\">Clinicial Care Options<\/a>, the other called <a href=\"http:\/\/www.practicepointhiv.com\/OpmanXXRegistration.aspx\" target=\"_blank\">Opman <\/a>&#8212; both now prominently include hepatitis as a substantial component of their conference agenda. In fact, both have even changed their names: &#8220;2012 Annual CCO HIV <strong>and Hepatitis C<\/strong> Symposium&#8221; and\u00a0&#8220;Optimal Management of HIV Disease <strong>&amp; Hepatitis<\/strong>&#8220;.<\/li>\n<li>Several of the larger clinical trials sites for HIV therapy now devote a significant proportion of their research efforts to HCV. The leader of a well-known site told me that <em>nearly <\/em><em>half<\/em> of their studies are now HCV-related.<\/li>\n<li>Many clinical ID practices (including ours) now openly solicit patients with HCV (not just HIV\/HCV co-infection).<\/li>\n<\/ul>\n<p>Of course, it&#8217;s easy to see why this is happening. These HCV cases call for all the skills we&#8217;ve sharpened over 16 years of combination antiretroviral therapy &#8212; managing complex regimens, myriad side effects, virologic responses, resistance, and drug-drug interactions.<\/p>\n<p>Then there&#8217;s the dynamic pace of HCV therapeutic research. Seemingly every week, there&#8217;s another major story, most of it happening too quickly for peer-reviewed medical journals.\u00a0See <a href=\"http:\/\/www.medscape.com\/viewarticle\/759011\" target=\"_blank\">here<\/a> for an example.<\/p>\n<p>Oh, and you get to cure people. Wow.<\/p>\n<p>By contrast, HIV therapy is in a plateau phase, with few major recent advances in treatment. The top four recommended initial regimens haven&#8217;t changed since 2009, and they are all remarkably effective. Clinical sessions of HIV follow-up have been likened to &#8220;well-baby checks&#8221;, a startling turnaround from the drama of HIV practice just a few years ago.<\/p>\n<p>Yawn. And I mean that in the best possible way. Patients are doing great!<\/p>\n<p>So if HIV\/ID specialists seem to be jumping on the HCV bandwagon, it&#8217;s completely understandable. Though whether gastroenterologists mind sharing this bandwagon with us is highly debatable &#8212; most would probably just as soon let us drive, given the current difference \u00a0in compensation between endoscopy and office management of medically and socially complex patients.<\/p>\n<p>Perhaps I should even rename this blog &#8220;HIV, <strong>HCV<\/strong>, and ID Observations&#8221;?<\/p>\n<p>Nah, it still needs a complete name overhaul &#8212; and I&#8217;m waiting for some good suggestions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The news that hepatitis C (HCV) has passed HIV as a cause of death in the United States got quite a bit of attention when it was first presented last year at ICAAC &#8212; and no doubt the published paper, in this week&#8217;s Annals of Internal Medicine,\u00a0will also cause a stir. In fact, I boldly [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,4,5,8],"tags":[159,408,423,477,676],"class_list":["post-2485","post","type-post","status-publish","format-standard","hentry","category-health-care","category-hiv","category-infectious-diseases","category-patient-care","tag-cco","tag-hcv","tag-hiv","tag-ias-usa","tag-opman"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=2485"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2485\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=2485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=2485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=2485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}