{"id":2635,"date":"2012-04-17T10:35:26","date_gmt":"2012-04-17T14:35:26","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=2635"},"modified":"2012-04-17T10:35:26","modified_gmt":"2012-04-17T14:35:26","slug":"easl-starts-tomorrow-get-ready-for-the-hcv-treatment-deluge","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/easl-starts-tomorrow-get-ready-for-the-hcv-treatment-deluge\/2012\/04\/17\/","title":{"rendered":"EASL Starts Tomorrow — Get Ready for the HCV Treatment Deluge"},"content":{"rendered":"

I can’t think of a single upcoming scientific meeting in ID that’s likely to be more “game changing” \u00a0— sorry for the tired metaphor — than the 47th European Association for the Study of the Liver (EASL) meeting, which starts tomorrow in Barcelona.<\/p>\n

As a hint of what’s to come, earlier this month Abbott released these data<\/a> on two studies of interferon-free treatments:<\/p>\n

In the study known as “Co-Pilot,” different doses of ABT-450\/r [a boosted HCV protease inhibitor], plus ABT-333 [a polymerase inhibitor] and ribavirin administered for 12 weeks showed sustained virological response at 12 weeks post treatment (SVR12<\/sub>) in 95\u00a0percent and 93\u00a0percent of treatment-na\u00efve genotype\u00a01 (GT1) patients. \u00a0In addition, SVR12<\/sub> was achieved in 47 percent of patients who were previous non-responders to past HCV treatment …\u00a0In a separate study, known as “Pilot,” 91\u00a0percent of genotype\u00a01 infected, treatment-na\u00efve patients taking ABT-450\/r and ABT-072 combined with ribavirin administered for 12 weeks, achieved sustained viral response at 24 weeks (SVR24<\/sub>).<\/p><\/blockquote>\n

To recap: That’s a > 90% cure rate for interferon-free, all oral regimens given for 12 weeks.<\/p>\n

Mind you, these are just three small studies<\/em> that could completely change how we treat this infection.<\/p>\n

How many more like it are in the wings?<\/p>\n

The bottom line is that anyone planning to start a patient on interferon-based HCV treatment today should weigh — very <\/em>carefully — the pros and cons of treating now, vs waiting a couple of years for what will undoubtedly be superior regimens.<\/p>\n","protected":false},"excerpt":{"rendered":"

I can’t think of a single upcoming scientific meeting in ID that’s likely to be more “game changing” \u00a0— sorry for the tired metaphor — than the 47th European Association for the Study of the Liver (EASL) meeting, which starts tomorrow in Barcelona. As a hint of what’s to come, earlier this month Abbott released […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,10],"tags":[24,26,408],"class_list":["post-2635","post","type-post","status-publish","format-standard","hentry","category-infectious-diseases","category-research","tag-abt-072","tag-abt-450","tag-hcv"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=2635"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/2635\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=2635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=2635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=2635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}