{"id":3320,"date":"2012-10-16T11:46:50","date_gmt":"2012-10-16T15:46:50","guid":{"rendered":"http:\/\/blogs.nejm.org\/?p=3320"},"modified":"2015-06-04T15:41:10","modified_gmt":"2015-06-04T19:41:10","slug":"some-liver-meeting-wow-studies-start-to-emerge","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/some-liver-meeting-wow-studies-start-to-emerge\/2012\/10\/16\/","title":{"rendered":"Some Liver Meeting “Wow!” Studies Start to Emerge"},"content":{"rendered":"

\"\"<\/a>The Liver Meeting,\u00a0the annual meeting of the American Association for the Study of Liver Disease, does not take place until November 9-13, in Boston.<\/p>\n

But if you want a preview, a couple of notable studies\u00a0have already been “announced” in the press.<\/p>\n

Specifically, there’s this<\/a>:<\/p>\n

Abbott today announced initial results from “Aviator,” a phase\u00a02b study of its interferon-free, investigational regimen for the treatment of hepatitis C (HCV). Initial results show sustained virological response at 12 weeks post treatment (SVR12) in 99\u00a0percent of treatment-na\u00efve (n=77) and 93\u00a0percent of null responders (n=41) for genotype\u00a01 (GT1) HCV patients taking a combination of ABT-450\/r, ABT-267, ABT-333 and ribavirin for 12 weeks, based on an observed data analysis.<\/p><\/blockquote>\n

That regimen contains 5 drugs<\/em> — HIV\/ID docs will recognize the “\/r” as familiar short hand for ritonavir boosting — but it’s hard to beat those response numbers. Note especially the 93% cure rate in interferon null responders — amazing.<\/p>\n

If 5 drugs seems like too many, there’s also this<\/a>:<\/p>\n

[Bristol-Myers Squibb]\u00a0said 94 percent of patients who took a combination of three experimental drugs, daclatasvir, asunaprevir, and BMS-791325, were cured in a 12-week study. Those patients did not take interferon or ribavirin.<\/p><\/blockquote>\n

Looks like it’s going to be an interesting meeting. That sentence may be the understatement of the year.<\/p>\n","protected":false},"excerpt":{"rendered":"

The Liver Meeting,\u00a0the annual meeting of the American Association for the Study of Liver Disease, does not take place until November 9-13, in Boston. But if you want a preview, a couple of notable studies\u00a0have already been “announced” in the press. Specifically, there’s this: Abbott today announced initial results from “Aviator,” a phase\u00a02b study of […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,8,10],"tags":[85,263,417,513,810],"class_list":["post-3320","post","type-post","status-publish","format-standard","hentry","category-infectious-diseases","category-patient-care","category-research","tag-asunaprevir","tag-daclatasvir","tag-hepatitis-c","tag-interferon","tag-ribavirin"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/3320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=3320"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/3320\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=3320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=3320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=3320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}