{"id":7989,"date":"2016-01-10T19:38:06","date_gmt":"2016-01-11T00:38:06","guid":{"rendered":"http:\/\/blogs.nejm.org\/hiv-id-observations\/?p=7989"},"modified":"2016-01-11T10:13:00","modified_gmt":"2016-01-11T15:13:00","slug":"medical-marijuana-and-painful-neuropathy-an-opportunity-to-make-us-believers","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/medical-marijuana-and-painful-neuropathy-an-opportunity-to-make-us-believers\/2016\/01\/10\/","title":{"rendered":"Medical Marijuana and Painful Neuropathy &#8212; An Opportunity to Make Us Believers"},"content":{"rendered":"<p><a href=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2016\/01\/hickey-pot-venn-diagram.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-7990\" src=\"http:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2016\/01\/hickey-pot-venn-diagram.png\" alt=\"hickey-pot-venn-diagram\" width=\"235\" height=\"279\" srcset=\"https:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2016\/01\/hickey-pot-venn-diagram.png 575w, https:\/\/blogs.nejm.org\/hiv-id-observations\/wp-content\/uploads\/sites\/2\/2016\/01\/hickey-pot-venn-diagram-253x300.png 253w\" sizes=\"auto, (max-width: 235px) 100vw, 235px\" \/><\/a>Medical marijuana is now <a href=\"http:\/\/www.nytimes.com\/2016\/01\/08\/nyregion\/first-medical-marijuana-dispensaries-in-new-york-are-poised-to-open.html?ref=health&amp;_r=0\" target=\"_blank\">officially available\u00a0in New York<\/a>, the city with\u00a0by far the largest number of people living with HIV\/AIDS in the country. Reporting on the first dispensary in Manhattan, the aptly named Julie Weed (yes! her real name!) <a href=\"http:\/\/www.forbes.com\/sites\/julieweed\/2016\/01\/09\/manhattans-first-medical-marijuana-dispensary-opens-week-and-is-working-with-mt-sinai-hospital\/\" target=\"_blank\">writes<\/a>:<\/p>\n<p style=\"padding-left: 30px\">One of the most promising areas for research is the substitution of medical marijuana for opioids like OxyContin and Percocet for pain management &#8230;\u201c68% of our patients with AIDS-related neuropathy have said that medical marijuana has allowed them to stop taking opioid prescription pain killers which can be addictive, cause a variety of harmful side-effects, and \u2014 most critically \u2013 are the cause of thousands of overdose deaths per year.\u201d<\/p>\n<p>Some thoughts based on this claim, and the long history of medical marijuana and HIV\/AIDS:<\/p>\n<ul>\n<li><strong>Could 68% of patients with painful peripheral neuropathy really stop opioid pain killers with marijuana?<\/strong> Wow. If that&#8217;s true, it&#8217;s <em>huge &#8212;\u00a0<\/em>even half this rate would be a dramatic advance.\u00a0Among the most frustrating conditions in all of medicine, painful peripheral neuropathy has a list of treatments as varied as the products sold in the &#8220;Cough and Cold&#8221; aisle at your pharmacy &#8212; and are, unfortunately, about equally\u00a0effective. Proven\u00a0strategies to help people come off chronic narcotics are badly needed.<\/li>\n<li><strong>HIV specialists have been hearing about the medical use of marijuana even longer than we&#8217;ve had effective antiretroviral therapy.\u00a0<\/strong>Initially touted as an appetite stimulant for HIV-related anorexia and weight loss, and as palliative therapy to ease the pain of death and dying, it\u00a0gained further use in the mid-1990s when early\u00a0HIV-related combination regimens\u00a0caused so much nausea. This\u00a0<strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17296917\" target=\"_blank\">randomized clinical trial<\/a><\/strong> led by Donald Abrams &#8212; who has done some of the best work studying marijuana in HIV <strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9692378\" target=\"_blank\">against great odds<\/a><\/strong> &#8212; found that 5 days of smoked cannabis was more effective than placebo in 50 patients with painful peripheral neuropathy. Of course blinding the study arms was (and remains) essentially\u00a0impossible given the euphoric effects of the drug, but maybe that&#8217;s the whole point.<\/li>\n<li><strong>Just legalize the stuff already.<\/strong> That&#8217;s how I&#8217;d characterize\u00a0the\u00a0opinion on marijuana for\u00a0the vast majority of the doctors, nurses, and social workers I work with, some of\u00a0whom (like me) both\u00a0remember Woodstock (the original one, kids) and enjoy the music from it, or are younger, and have the same view. If marijuana is\u00a0legalized, it can be more easily\u00a0regulated, taxed, and studied (see below) &#8212; just like that other legal psychoactive drug, alcohol. Seems like this is <strong><a href=\"http:\/\/fivethirtyeight.com\/datalab\/chris-christie-newfound-drug-warrior-is-too-late-to-stop-pot\/\" target=\"_blank\">hardly a minority view<\/a>\u00a0<\/strong>(the link is to the source of the graphic at the top of the page).<\/li>\n<li><strong>Legalization\u00a0would allow more rigorous\u00a0studies of therapeutic\u00a0use, long-term effects, and safety.<\/strong>\u00a0Such studies are now essentially\u00a0prohibited by the federal government since marijuana\u00a0is considered a drug of abuse. As a result, many claims about its\u00a0medical indications\u00a0are based on either <strong><a href=\"http:\/\/jama.jamanetwork.com\/article.aspx?articleid=2338251\" target=\"_blank\">small, short term, or methodologically questionable studies<\/a><\/strong> or, even worse, strongly-held beliefs based mostly on anecdote &#8212; the weakest form of scientific evidence. That is, I&#8217;m afraid, what that &#8220;68% have stopped their opiates&#8221; claim is from the opening paragraph. Until it&#8217;s studied more rigorously, we&#8217;re stuck with the frustration of dealing with claims that marijuana is a valid treatment for practically every chronic condition under the sun. A similar claim might be made of benzodiazepines like Valium, Xanax, and\u00a0Klonopin &#8212; which definitely make people feel better &#8212; but clinical research has more clearly defined both the\u00a0benefits and risks of this drug class.<\/li>\n<li><strong>The quasi-medical\u00a0atmosphere of some marijuana dispensaries is a huge\u00a0negative to the acceptance of legitimate medical use.<\/strong>\u00a0Got a\u00a0free 10 minutes? That plus saying you have &#8220;insomnia&#8221; <strong><a href=\"http:\/\/www.thedailybeast.com\/articles\/2014\/06\/24\/i-got-a-weed-license-in-minutes.html\" target=\"_blank\">gets you a weed license\u00a0for the medical stuff<\/a>\u00a0<\/strong>in Venice, no medical records required. Medical marijuana exists in this bizarre\u00a0parallel system to &#8220;real&#8221; FDA approved drugs, and the absence of good scientific data means that the indications for use state-by-state are literally and figuratively <strong><a href=\"https:\/\/www.leafly.com\/news\/health\/qualifying-conditions-for-medical-marijuana-by-state\" target=\"_blank\">all over the map.<\/a><\/strong> Got to love this indication (and I use the word loosely) for medical use from California: &#8220;Any other chronic or persistent medical symptom that substantially limits the ability of the person to conduct one or more major life activities (as defined by the Americans with Disabilities Act of 1990) or, if not alleviated, may cause serious harm to the patient&#8217;s safety or physical or mental health.&#8221; If it&#8217;s based on patient report, that covers pretty much anything, doesn&#8217;t it?<\/li>\n<\/ul>\n<p>So what&#8217;s my take right now? Count me in the same camp as these authors,\u00a0who <a href=\"http:\/\/jama.jamanetwork.com\/article.aspx?articleid=2338230\" target=\"_blank\">published their views in a <em>JAMA<\/em> editorial last year<\/a>, writing:<\/p>\n<blockquote><p>If the states\u2019 initiative to legalize medical marijuana is merely a veiled step toward allowing access to recreational marijuana, then the medical community should be left out of the process, and instead marijuana should be decriminalized &#8230;\u00a0Evidence justifying marijuana use for various medical conditions will require the conduct of adequately powered, double-blind, randomized, placebo\/active controlled clinical trials to test its short- and long-term efficacy and safety. The federal government and states should support medical marijuana research.<\/p><\/blockquote>\n<p>Totally agree. Meanwhile, here&#8217;s a study design free\u00a0for the taking:<\/p>\n<p style=\"padding-left: 30px\"><strong>Title:<\/strong> A randomized, blinded study of cannabis versus placebo to reduce opiate use in HIV-related\u00a0neuropathic pain.<br \/>\n<strong>Entry criteria:<\/strong> \u00a0Painful HIV-related neuropathy\u00a0for \u22653 months, confirmed by a neurologist at screening,\u00a0and requiring the use of opiates for control. Stable doses of opiates for at least 4 weeks prior to screening are required. HIV RNA\u00a0must be &lt; 50 copies\/mL\u00a0on non-neurotoxic containing ART.<br \/>\n<strong>Intervention:<\/strong> \u00a0Smoked cannabis or placebo for 24\u00a0weeks; up to daily use as desired by study subjects. Adjunctive therapies (gabapentin, antiepileptics, non-steroidal anti-inflammatory drugs, acupuncture) will be administered at the discretion of the investigators.<br \/>\n<strong>Primary endpoint:<\/strong> \u00a0Time to cessation of opiate use as estimated\u00a0by the Kaplan-Meier method.<br \/>\n<strong>Secondary endpoints:<\/strong>\u00a0 Time to reduction in 25, 50, and 75% of opiate use; absolute and relative reduction in opiate dose. Proportion opiate free at study completion. And what the hell, might as well also do Numeric Pain Rating Scale, Change in Pain Inventory Score,\u00a0Numeric Rating Scale Sleep Interference Score, Medical Outcomes Study Sleep Scale, Patient Global Impression of Change of Pain, and all those other neuropathy assessments. Throw in some neurocognitive testing just for fun.<br \/>\n<strong>Funding:<\/strong> \u00a0National Institutes of Health<\/p>\n<p>You&#8217;re welcome!<\/p>\n<p>Let&#8217;s see if what you think.<\/p>\n<div id=\"polls-34\" class=\"wp-polls\">\n\t<form id=\"polls_form_34\" class=\"wp-polls-form\" action=\"\/index.php\" method=\"post\">\n\t\t<p style=\"display: none;\"><input type=\"hidden\" id=\"poll_34_nonce\" name=\"wp-polls-nonce\" value=\"cc2dd91abe\" \/><\/p>\n\t\t<p style=\"display: none;\"><input type=\"hidden\" name=\"poll_id\" value=\"34\" \/><\/p>\n\t\t<p style=\"text-align: center;\"><strong>What should we do with marijuana?<\/strong><\/p><div id=\"polls-34-ans\" class=\"wp-polls-ans\"><ul class=\"wp-polls-ul\">\n\t\t<li><input type=\"radio\" id=\"poll-answer-109\" name=\"poll_34\" value=\"109\" \/> <label for=\"poll-answer-109\">Legalize, regulate, and study it like alcohol.<\/label><\/li>\n\t\t<li><input type=\"radio\" id=\"poll-answer-110\" name=\"poll_34\" value=\"110\" \/> <label for=\"poll-answer-110\">Decriminalize and study it, and reserve for medical use only, like benzodiazepines.<\/label><\/li>\n\t\t<li><input type=\"radio\" id=\"poll-answer-111\" name=\"poll_34\" value=\"111\" \/> <label for=\"poll-answer-111\">Leave things as they are now.<\/label><\/li>\n\t\t<\/ul><p style=\"text-align: center;\"><input type=\"button\" name=\"vote\" value=\"   Vote   \" class=\"Buttons\" onclick=\"poll_vote(34);\" \/><\/p><p style=\"text-align: center;\"><a href=\"#ViewPollResults\" onclick=\"poll_result(34); return false;\" title=\"View Results Of This Poll\">View Results<\/a><\/p><\/div>\n\t<\/form>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Medical marijuana is now officially available\u00a0in New York, the city with\u00a0by far the largest number of people living with HIV\/AIDS in the country. Reporting on the first dispensary in Manhattan, the aptly named Julie Weed (yes! her real name!) writes: One of the most promising areas for research is the substitution of medical marijuana for [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,4,9],"tags":[423,1112],"class_list":["post-7989","post","type-post","status-publish","format-standard","hentry","category-health-care","category-hiv","category-policy","tag-hiv","tag-marijuana"],"post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/7989","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/comments?post=7989"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/posts\/7989\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/media?parent=7989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/categories?post=7989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/hiv-id-observations\/index.php\/wp-json\/wp\/v2\/tags?post=7989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}