About Ishani Ganguli

Ishani Ganguli

All posts by Ishani Ganguli

In Myelofibrosis, Relief with Halting the Cytokine Storm

• February 29th, 2012

An older patient comes to you with severe night sweats, debilitating fatigue, abdominal pain, weight loss, and itching. High on your differential is myelofibrosis, the proliferative blood disorder that scars the bone marrow, causing abnormal blood counts and a spleen swollen with the effort of producing blood cells. We think the disease stems from dysregulation of… Read More…


Incidence of Adenocarcinoma in Barrett’s Esophagus

• October 12th, 2011

Lately, in our efforts to strike that tenuous balance between help and harm in cancer screening, we have erred on the side of doing less. Some guidelines now ask us to wait until 50 years of age to screen women for breast cancer.  And we now have evidence that most men are better off if… Read More…


Incidence of Adenocarcinoma in Barrett's Esophagus

• October 12th, 2011

Lately, in our efforts to strike that tenuous balance between help and harm in cancer screening, we have erred on the side of doing less. Some guidelines now ask us to wait until 50 years of age to screen women for breast cancer.  And we now have evidence that most men are better off if… Read More…


An effective hormonal treatment for castration-resistant prostate cancer?

• May 25th, 2011

Prostate cancer is a hormonally driven illness that, for 70 years, has been treated in kind—by blocking androgen production or wasting its supplies. But once metastatic prostate cancer resisted the depleting effect of castration or the castrating chemotherapy agents, it was commonly believed the disease had escaped androgen regulation and hormonal agents would no longer… Read More…


Reducing Transmission of Resistant Bacteria in ICUs

• April 13th, 2011

Health care-associated infections harm patients and consume limited resources. Such infections with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) have become a popular target for lawmakers and regulators to improve quality, and some prevention efforts have been codified. However, we still don’t have a good sense of which efforts are worthwhile. Two studies in… Read More…


Inhaler Wars: Tiotropium versus Salmeterol for Chronic Obstructive Pulmonary Disease

• March 23rd, 2011

COPD sufferers know the symptoms all too well: the phlegmy cough, gasping wheezy breaths, and chest tightness that signal an exacerbation. Guidelines recommend inhaled long-acting bronchodilators—either an anticholinergic or a β2-agonist—to mitigate symptoms and reduce the frequency of these exacerbations in patients with moderate to severe disease. Which one is more effective? Without large head-to-head… Read More…


Diuretic Strategies in Heart Failure

• March 2nd, 2011

For decades, when patients come in with acute heart failure, doctors have reached for the powerful loop diuretic furosemide. How much of the drug should we give? And is it better to dose it continuously or in discrete boluses? These questions are often debated on morning rounds and answered using personal experience, but there has been… Read More…


A Cheap, Targeted Treatment for Retinopathy of Prematurity

• February 16th, 2011

Newborns who emerge too early face a world of problems. One of these is the propensity for retinal blood vessels to grow amuck in response to erratic biochemical signals; these vessels can bleed and scar, leading to retinopathy of prematurity (ROP) — a major cause of childhood blindness in the developed and developing worlds. Ophthalmologists usually… Read More…


For young men HPV vaccine protects against warts, and all?

• February 2nd, 2011

Human papilloma virus (HPV) is the sexually-transmitted organism that is the most common cause of anogenital warts and cancers—depending on gender—of the cervix, penis, mouth, and anus. Research on HPV prophylaxis has traditionally focused on females, since cervical cancer is the most prevalent of the virus’ oncogenic outcomes. A four-pronged vaccine against some of the… Read More…