About James Yeh, M.D. M.P.H.

James Yeh, M.D. M.P.H.

James is a 2015-2016 NEJM Editorial Fellow. He recently completed fellowship in General Internal Medicine at Brigham and Women’s Hospital. He is interested in evidence-based medicine, medical education, knowledge translation, and pharmacoepidemiology.

All posts by James Yeh, M.D. M.P.H.

Reversal of Factor Xa Inhibitor-Associated Acute Major Bleeding

• September 23rd, 2016

Use of anticoagulants It is estimated that slightly more than 1 in 7 strokes is due to atrial fibrillation. The use of anticoagulants reduces this risk of thromboembolism. In recent years, a number of direct oral anticoagulants (such as apixaban, rivaroxaban, and edoxaban) that inhibit active coagulation factor X have been approved for stroke prevention in… Read More…


Asthma Risk, Farming, and Innate Immunity

• August 3rd, 2016

Mrs. Newton and Janice, her 2-year-old daughter, are seeing you for a child wellness check-up.  Mrs. Newton asks you about asthma risks and reports that she’s read somewhere in a parenting magazine that letting children play in the dirt and be exposed to animals reduces risks of asthma and allergies.  She asks what you know… Read More…


Sudden Cardiac Death in the Young

• June 22nd, 2016

Fatal heart conditions are shocking and tragic when they are sudden and unexpected, and especially when they occur in the young. Occasionally the public is reminded of this via a news story of a high school or professional athlete who collapses suddenly and dies during a sporting event. Often, the first manifestation of a serious… Read More…


Primary Prevention of Cardiovascular Events — A Pragmatic Approach

• May 25th, 2016

Ms. Barnstable is a 66 year-old woman who is seeing you for an annual physical check-up today.  She does not take any medications and is a smoker.  She asks if there are drugs that she should be taking to lower her risks for heart attacks and strokes. Besides smoking cessation counseling, what do you tell… Read More…


Motivating Change in Physicians’ Prescribing Behavior

• March 16th, 2016

High-risk prescribing Drug prescribing is one of the armamentarium in a physician’s tool box to help manage disease and alleviate suffering. However, the risks of certain drugs in particular clinical contexts outweigh the benefits and may lead to preventable drug-related morbidity and mortality. Such high-risk prescribing is a common concern. What is the safer prescribing trial about? In… Read More…


Bariatric Surgery Outcome in Adolescents

• January 13th, 2016

You are seeing Anna Boylston in your adolescent primary care clinic today.  You have been her PCP since she was 10 years-old.  She is now 14 and has a history of severe obesity (current BMI 37 kg/m2). She and her family ask you about bariatric surgery options for teenagers and the long term benefits and… Read More…


Risks for Second Cancer After Hodgkin’s Lymphoma Therapy

• December 23rd, 2015

You are meeting Mrs. Mason in your primary care clinic for the first time today. She has a history of Hodgkin’s lymphoma and was treated with chemotherapy and radiation therapy over 25 years ago. You wonder what is her risk for additional cancers as a result of treatment for Hodgkin’s lymphoma? While the use of radiation… Read More…


Cardiovascular Safety of Empagliflozin in Patients with Type 2 Diabetes

• November 25th, 2015

You are a primary care provider and you’ve heard about a new class of anti-diabetic drugs called the “flozins,” including empagliflozin. You wonder what this drug class is and what we know about its safety and its effect on cardiovascular events. What is empagliflozin? Empagliflozin is a sodium-glucose transporter-2 (SGLT-2) inhibitor. Since glucose is freely filtered in… Read More…


Blood Pressure Control: SPRINTing Towards a Lower Blood Pressure Target

• November 9th, 2015

Mrs. Weymouth has hypertension and she is at your office for a check-up. Her blood pressure is 136/72 mm Hg. What do you tell her about her blood pressure control? Hypertension affects nearly 1 out of 2 individuals world-wide between the ages of 35 and 70. The goal of blood pressure control is to reduce cardiovascular… Read More…


How to “Nudge” Smokers to Reduce Tobacco Use?

• September 30th, 2015

Health problems due to smoking account for 6 million deaths annually and are the leading cause of death worldwide. Despite the dramatic reduction of smoking rates in the past 50 years in the U.S., nearly 18% of adults are current smokers. Each day 2100 youth and young adults become regular daily smokers. As nicotine sustains… Read More…