Scorpion Envenomation

Posted by • August 1st, 2014

Each year more than a million cases of scorpion envenomation occur worldwide, causing substantial morbidity and, among children, a risk of death. A new brief review discusses the effects and treatment of scorpion envenomation. Every year, more than 1 million cases of scorpion envenomation are reported worldwide. Although the resultant mortality is lower than that from snake envenomation, there is substantial morbidity and, among children, a risk of death.

Clinical Pearls

What are the general characteristics of scorpion stings?

Most scorpion stings cause localized pain, whereas only an estimated 10% of stings, even from the most dangerous scorpions, result in severe systemic envenomation. Edema, erythema, paresthesias, muscle fasciculations, and numbness may occur at the site of the sting. It is often difficult to see the sting site or to identify inflammation at the site, despite substantial local pain. Most cases of severe envenomation occur in children. Systemic envenomation is characterized by neuromuscular abnormalities resulting from effects on the somatic and cranial nerves, both cholinergic and adrenergic excitation of the autonomic nervous system, pulmonary edema, and cardiac effects.

What are the autonomic effects of scorpion stings?

Excitation of the autonomic nervous system is characterized by both parasympathetic and sympathetic responses. Parasympathetic, cholinergic effects may include hypersalivation, profuse diaphoresis, lacrimation, miosis, diarrhea, vomiting, bradycardia, hypotension, increased respiratory secretions, and priapism. Sympathetic, adrenergic effects include tachycardia, hypertension, mydriasis, hyperthermia, hyperglycemia, agitation, and restlessness. Whereas most parasympathetic effects tend to occur early, sympathetic effects persist because of the release of catecholamines and are responsible for severe envenomation.

Morning Report Questions

Q: What are possible cardiovascular complications of scorpion envenomation?
A: A range of cardiac conduction abnormalities occur in about one third to one half of patients with systemic envenomation. These effects include atrial tachycardia, ventricular extrasystoles, T-wave inversion, ST-T wave changes, and, less frequently, bundle-branch block. Increased autonomic stimulation caused by increased vagal effects on the heart and sympathetic stimulation are the probable causes of these effects. Hypertension is common and occurs early in response to sympathetic stimulation. Hypotension is less common, occurs with the development of severe envenomation, and often requires intervention with vasopressors and fluid resuscitation. Many factors are at play in the development of hypotension, with cholinergic stimulation causing vasodilation, fluid loss, and myocardial depression. Cardiac dysfunction resulting from catecholamine-induced myocarditis and myocardial ischemia complicates severe envenomation from androctonus, buthus, mesobuthus, and tityus scorpions. This complication may result in pulmonary edema and cardiogenic shock.

Figure 1. Pathophysiological and Clinical Effects of Systemic Scorpion Envenomation.

Q: What are the principles of treatment for cases of severe scorpion envenomation?
A: The specific treatment is the administration of antivenom combined with symptomatic and supportive treatment, including prazosin and dobutamine in patients with cardiovascular toxic effects and benzodiazepines when there is neuromuscular involvement. Symptoms related to the site of the sting should be managed with appropriate analgesia with acetaminophen and antiinflammatory agents, depending on severity. Once severe envenomation has developed, the administration of antivenom may be less effective, since its primary therapeutic action is to bind toxins; it does not reverse established pathophysiological injury, such as excess levels of catecholamine, pulmonary edema, and cardiogenic shock.

Table 1. Treatment of Scorpion Stings According to Clinical Grade. 

4 Responses to “Scorpion Envenomation”

  1. dr suryakant dhoke md says:

    Nice information,in indja mahadashtra esoecially konkan area mesobuthus bite is common wth parasymlathetic florid manifestations.if untreated may b fatal even jn adults,tretment is variable depending c fs,includes prazosin. Anti scorpion venom serum which is monovalent,treament of shock ,arrhythmias,,ace inhbtors n so on.

  2. Henrique Caldeira says:

    The cardiovascular symptoms due to scorpionic toxins(proteins) are centrally regulated.
    Therefore both, child and elderly people, are more susceptible to have cases of severe envenomation due to an increased permeability of the blood-brain barrier.

  3. Dr Bouhentala says:

    In Algeria we deal so much with the scorpion envenomation especially in th Sahara, from my experience I can tell you that the severty of the envenomation is closely related the type of the scorpion and the precocity of the treatement

  4. Dr. Murthy KRK says:

    We have demonstrated the efficacy of administration of insulin -glucose infusion in the scorpion sting victims based on our animal studies. Scorpion envenoming causes severe autonomic storm releasing massive amounts of counter-regulatory hormones (catechol amines, glucagon, glucocorticoids, thyroid hormones) and simultaneous suppression of insulin secretion releasing a sudden increase in free fatty acids which are toxic. Scorpion envenoming syndrome is a syndrome of fuel-energy deficits. Insulin administration acts against the actions of released counter-regulatory hormones, reverses severe pulmonary edema (ARDS), cardio-vascular changes, metabolic changes and all the clinical manifestations. Prazosin is a alpha blocker and acts by release of insulin. Insulin is the physiological antagonist to treat the scorpion envenoming syndrome