Posts Tagged ‘IBD’

TNF Inhibitors for Inflammatory Bowel Disease

Posted by • August 23rd, 2013

In the latest review article in our Clinical Therapeutics series, a 35-year-old man presents with an exacerbation of Crohn’s disease. Treatment with a TNF inhibitor is recommended. TNF inhibitors block the effects of the proinflammatory cytokine TNF-α, and several have been shown to be effective in treating inflammatory bowel disease. Inflammatory bowel disease, an umbrella term… Read More…

Vedolizumab Therapy for Ulcerative Colitis and Crohn’s Disease

Posted by • August 21st, 2013

A friend of mine, who has spent 15 years dealing with the ebbs and flows of ulcerative colitis (UC), is the kind of patient who would hope her physician pays attention to the results of two RCTs published this week in NEJM. She is one of an estimated 1.4 million Americans diagnosed with UC or… Read More…

Complex Cause of Pleuritic Chest Pain

Posted by • November 2nd, 2012

In the latest article in our Clinical Problem-Solving series, a 33-year-old man presented to the emergency department with pain in the right side of his chest. The pain had started 5 days earlier and was worse with deep inspiration and recumbency. He also noted mild swelling of his lower legs over the preceding several weeks. Ulcerative… Read More…