Posts Tagged ‘lung function’

Loss of FEV1 and the pathogenesis of COPD

Posted by • July 8th, 2015

For years, the dominant model for the pathogenesis of chronic obstructive pulmonary disease (COPD) has been that exposure to particulate matter (usually tobacco smoke) leads to a rapid decline in lung function, i.e., more than 40ml of FEV1 per year. This paradigm has recently come into question, but a careful study to test this model… Read More…

Improved Air Quality and Lung Development in Children

Posted by • March 4th, 2015

In 1905, the Public Health Congress convened in London, where Dr. Henry Antoine des Voeux presented a paper entitled “Fog and Smoke.”  In it, he described the characteristic black smoky fog – or “smog” – that enveloped London and many of the world’s other urban centers.  Credited with coining this new term, Dr. des Voeux… Read More…

A CFTR Potentiator in Treatment of Cystic Fibrosis

Posted by • November 2nd, 2011

A child born with cystic fibrosis (CF) as recently as four decades ago couldn’t expect to live much beyond age 10.  Now, therapeutic advances have increased that median survival to over 37 years.  Current interventions, however –airway clearance, antibiotic prophylaxis, exercise and nutrition among them – are based largely on slowing the inevitable progression of… Read More…

Lung Function in Rescue Workers at the World Trade Center after 7 Years

Posted by • April 7th, 2010

Following the September 11, 2001, terrorist attacks on the World Trade Center, rescue workers, volunteers, and residents of lower Manhattan were exposed to a dense, persistent dust cloud of pulverized building materials and chemical by-products of combustion or pyrolysis, known as “World Trade Center dust.” Studies have shown that those present during the collapse or… Read More…