Posts Tagged ‘metastatic melanoma’

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Posted by • November 2nd, 2016

Oncologists and patients with cancer eagerly await new therapies that efficiently target cancer and avoid damage to normal tissues. In 2015, a randomised controlled trial investigated the role of two immune checkpoint inhibitors: ipilimumab — an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibody — and nivolumab — an anti-programmed death-1 (PD-1) antibody. Patients with untreated metastatic… Read More…

A 68-Year-Old Man with Metastatic Melanoma

Posted by • July 12th, 2013

In the latest Case Record of the Massachusetts General Hospital, a 68-year-old man presented with metastatic melanoma to the groin and pelvis 11 years after excision of a superficial spreading melanoma on the right leg. A diagnostic test was performed, and management decisions were made.      Metastatic melanoma involving the central nervous system is associated with a… Read More…

Melanoma Treatment

Posted by • August 27th, 2010

Many melanomas contain an activating mutation in BRAF. In a study of a new agent, PLX4032, that inhibits mutated BRAF, 26 of 32 patients (81%) who received PLX4032 had a partial or complete response lasting at least 19 months. Metastatic melanoma is an aggressive disease for which there are few effective therapies. Clinical Pearls • What are… Read More…

Metastatic Melanoma

Posted by • August 20th, 2010

In the Original Article, Improved Survival with Ipilimumab in Patients with Metastatic Melanoma, Hodi et al. report that patients with metastatic melanoma who received an antibody to CTLA-4 (ipilimumab) with or without a gp100 vaccine survived nearly 4 months longer than did those who received the gp100 vaccine alone. The World Health Organization (WHO) estimates that… Read More…