Posts Tagged ‘myeloproliferative disorders’

Calreticulin (CALR): A new player in the mutational landscape of myeloproliferative disorders

Posted by • December 18th, 2013

Advances in molecular biology and sequencing technology have expanded our understanding of myeloproliferative disorders while aiding in the identification of the molecular defects that underlie these diseases. The first among these discoveries was the identification of the oncogenic fusion protein Bcr-abl in CML. Subsequent work lead to the discovery of a small molecule inhibitor, imatinib… Read More…

Simple and Complex

Posted by • January 4th, 2013

In the latest article in our Clinical Problem-Solving series, a 44-year-old man presented to the emergency department with chest pain that had started 1 hour earlier and had awakened him from sleep. The pain was severe, substernal, burning, radiating to the left arm, and accompanied by nausea and vomiting. When a myocardial infarction occurs in a… Read More…