For patients with moderate-to-severe atopic dermatitis, topical therapies have limited efficacy, and systemic treatments are associated with substantial toxic effects. Thus, there is an unmet need for effective and safe long-term medications for these patients. Simpson et al. reported the results of two phase 3 trials of dupilumab monotherapy (SOLO 1 and SOLO 2) in… Read More…
Posts Tagged ‘placebo’
Semaglutide in Patients with Type 2 Diabetes
Posted by Carla Rothaus • November 10th, 2016
Regulatory guidance specifies the need to establish cardiovascular safety of new diabetes therapies in patients with type 2 diabetes in order to rule out excess cardiovascular risk. The preapproval Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) conducted by Marso et al. was designed to assess… Read More…
Liraglutide in Type 2 Diabetes
Posted by Carla Rothaus • July 28th, 2016
To assess the long-term effects of liraglutide on cardiovascular outcomes and other clinically important events, the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial was initiated in 2010. Patients with type 2 diabetes who had a glycated hemoglobin level of 7.0% or more were eligible if they either had not… Read More…
Perioperative Bridging Anticoagulation
Posted by Carla Rothaus • August 28th, 2015
In this Original Article, a trial assigned patients with atrial fibrillation who required warfarin interruption for an elective procedure to either bridging anticoagulation or placebo. Forgoing bridging was noninferior to bridging for arterial thromboembolism and superior for major bleeding. A video summary is also available with the article on NEJM.org. For patients with atrial fibrillation who… Read More…
Pleural Infection
Posted by Graham McMahon • August 12th, 2011
Slowly clearing infections in the pleural space are a source of substantial morbidity. A new study published this week in NEJM showed that instillation of recombinant DNase and tissue plasminogen activator (t-PA) is more effective than placebo in clearing radiographic pleural effusions. The mortality rate from pleural infection is between 10% and 20%. The investigators in… Read More…
Breathing Easy
Posted by Rena Xu • July 13th, 2011
If a treatment for asthma makes an asthma patient feel better, did it work? It’s hard to say, according to an article by Wechsler et al published this week in NEJM. The authors report the results of a randomized double-blind crossover pilot study comparing the effectiveness of four interventions: an active albuterol inhaler, a placebo… Read More…
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