Posts Tagged ‘PML’

Vedolizumab Therapy for Ulcerative Colitis and Crohn’s Disease

Posted by • August 21st, 2013

A friend of mine, who has spent 15 years dealing with the ebbs and flows of ulcerative colitis (UC), is the kind of patient who would hope her physician pays attention to the results of two RCTs published this week in NEJM. She is one of an estimated 1.4 million Americans diagnosed with UC or… Read More…

Natalizumab-Associated PML

Posted by • May 16th, 2012

A new study found that in patients treated with natalizumab, PML incidence was about 11 cases per 1000 patients with 25 to 48 months of treatment, prior immunosuppressant use, and anti–JC virus antibody–positive status. The incidence was estimated to be 0.09 cases or fewer per 1000 antibody-negative patients. Natalizumab (Tysabri, Biogen Idec and Elan Pharmaceuticals) is approved… Read More…

Frontal Encephalopathy

Posted by • April 16th, 2010

Many disorders cause confusional states, ranging from easily reversible medication effects to life-threatening illnesses; often multiple factors coexist in a given patient.The latest Case Record of the Massachusetts General Hospital is A 69-Year-Old Woman with Lethargy, Confusion, and Abnormalities on Brain Imaging. Clinical Pearls • How do frontal-lobe disorders present? Apathy, perseveration, decreased verbal fluency, and gait… Read More…