Posts Tagged ‘ruxolitinib’

Simple and Complex

Posted by • January 4th, 2013

In the latest article in our Clinical Problem-Solving series, a 44-year-old man presented to the emergency department with chest pain that had started 1 hour earlier and had awakened him from sleep. The pain was severe, substernal, burning, radiating to the left arm, and accompanied by nausea and vomiting. When a myocardial infarction occurs in a… Read More…

Ruxolitinib for Myelofibrosis

Posted by • March 2nd, 2012

A new trial from Verstovsek and others showed clinically significant responses in spleen size and quality of life among patients with myelofibrosis receiving the ruxolitinib, a JAK1 and JAK2 inhibitor. The agent has some myelotoxicity, but this study showed a survival advantage with ruxolitinib. Myelofibrosis, a myeloproliferative neoplasm, is manifested by abnormal blood counts (anemia, thrombocytosis or… Read More…

In Myelofibrosis, Relief with Halting the Cytokine Storm

Posted by • February 29th, 2012

An older patient comes to you with severe night sweats, debilitating fatigue, abdominal pain, weight loss, and itching. High on your differential is myelofibrosis, the proliferative blood disorder that scars the bone marrow, causing abnormal blood counts and a spleen swollen with the effort of producing blood cells. We think the disease stems from dysregulation of… Read More…