Posts Tagged ‘tuberculosis’

Tuberculosis

Posted by • December 9th, 2011

Treatment of latent TB is an important public-health strategy, but 9 months of daily isoniazid (270 doses) poses challenges for compliance. In a new study, 3 months of weekly isoniazid plus rifapentine (12 doses) was found to be noninferior to 9 months of isoniazid alone. Tuberculosis results in nearly 2 million deaths annually worldwide. Treatment of… Read More…

Antiretroviral Therapy and Tuberculosis

Posted by • October 21st, 2011

When to initiate antiretroviral therapy in patients with newly diagnosed HIV infection and TB has been debated. In a new study from Cambodia, giving antiretrovirals 2 weeks after the start of TB therapy was superior to therapy begun at 8 weeks, with a decrease in mortality. Tuberculosis is a major cause of death in persons infected… Read More…

Prevention of HIV Transmission

Posted by • August 12th, 2011

In a large, international study of HIV-1–serodiscordant couples, the receipt of antiretroviral therapy by the infected partner decreased transmission to the uninfected partner as well as rates of clinical events in the HIV-1–infected partner. Because the sexual transmission of HIV-1 from infected persons to their partners is strongly correlated with concentrations of HIV-1 in blood and in the… Read More…

Treatment as Prevention

Posted by • August 10th, 2011

Just for a moment, imagine that you’ve just finished treating me for active pulmonary tuberculosis. I’m cured and therefore happy. What’s more, my future roommates are happy: I’ll no longer aerosolize inocula of acid-fast bacilli with each chesty cough, and they won’t even be exposed to the disease. Even my future roommates’ future roommates probably… Read More…

Latent Tuberculosis

Posted by • April 15th, 2011

The latest article in our Clinical Practice review series, Latent Tuberculosis Infection in the United States, comes from Drs. C. Robert Horsburgh, Jr. of Boston University School of Public Health and Eric J. Rubin of Harvard School of Public Health. There is no way to detect the presence of latent Mycobacterium tuberculosis in an individual patient… Read More…

Multidrug-Resistant Tuberculosis

Posted by • September 10th, 2010

The latest article in our Current Concepts review series, “MDR Tuberculosis — Critical Steps for Prevention and Control,” comes from the Stop TB Department at the World Health Organization in Geneva. Multidrug-resistant (MDR) tuberculosis is defined as disease caused by strains of Mycobacterium tuberculosis that are at least resistant to treatment with isoniazid and rifampicin. Extensively… Read More…

TB or Not TB? Hoping for Fast and Reliable Answers to an Age-Old Question

Posted by • September 8th, 2010

In the summer after my second year of medical school, I found myself in a hospital clinic in Swaziland with what was quickly becoming a familiar scenario:  An unwell-looking woman from a remote village had traveled for many hours to seek our opinion on her cough and night sweats.  Was it tuberculosis? It was a frustratingly… Read More…