Posts Tagged ‘vaccine’

Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older

Posted by • September 15th, 2016

An investigational herpes zoster subunit vaccine (HZ/su) is being evaluated for the prevention of herpes zoster and postherpetic neuralgia in adults 50 years of age or older. A previous trial (Zoster Efficacy Study in Adults 50 Years of Age or Older [ZOE-50]) showed that HZ/su had a vaccine efficacy against herpes zoster of 97.2%, which… Read More…

Intussusception Risk after Rotavirus Vaccination

Posted by • February 5th, 2014

Rotavirus vaccines have emerged as important vaccines in preventing severe childhood diarrhea and, in low-income countries, deaths.  As a class of vaccines, they have accelerated the development of surveillance systems to monitor vaccine safety. Two trials recently published in NEJM evaluated the risk of intussception in young infants in the context of the overall health benefits… Read More…

A Mumps Outbreak that Shows the Vaccine is Still Working

Posted by • November 5th, 2012

Recently, New York City suffered flooding, fires, power outages, and many deaths after a superstorm that cycled into the city from the Atlantic.  Throughout history, cities particularly suffer from singular natural or man-made events because of their population density.  Crowded conditions also make cities rife ground for the transmission of contagious disease – yellow fever,… Read More…

Natural Rotavirus Infection in an Indian Birth Cohort: How Much Protection Does It Give?

Posted by • July 27th, 2011

Rotaviruses cause more than half a million deaths each year, and approximately 23 percent of these deaths occur in India. There are two vaccines available for use to prevent rotavirus gastroenteritis in infants and children: RotaTeq and Rotarix. But RotaTeq was introduced in India only earlier this year, and access to it is limited. Oral vaccines… Read More…

HPV Vaccination in Males

Posted by • February 4th, 2011

Limited data on the efficacy of the quadrivalent HPV vaccine are available for males. In this trial from Giuliano et al. involving 4065 healthy boys and young men 16 to 26 years of age, the quadrivalent vaccine against HPV reduced the occurrence of external genital lesions by 60%. Human papillomavirus (HPV) infects the squamous epithelium in… Read More…

Polio Eradication: New Progress toward an Elusive Target

Posted by • June 23rd, 2010

The quest to eradicate poliovirus has been ongoing for more than 20 years, but today, despite a 99% reduction in the annual incidence of paralytic poliomyelitis, eradication remains a largely unattained goal. This is not for a lack of trying. The Global Poliomyelitis Eradication Initiative (GPEI) of the World Health Organization (WHO) has spent more than… Read More…