Posts in the ‘Physicians-In-Training’ Category

The posts below are excerpted from the NEJM Resident e-Bulletin, a free weekly email of teaching topics. Including the content here in Now@NEJM enables you to have a conversation or ask questions about clinical points that interest you. To receive the email version, register as a student or resident on NEJM.org. These posts can now be found on NEJM Resident 360.

Screening for Colorectal Neoplasia

Posted by • January 6th, 2017

The percentage of U.S. residents with up-to-date screening for colorectal cancer has not increased appreciably since 2010 and remains at approximately 60%. The National Colorectal Cancer Roundtable has established a goal of 80% adherence to colorectal cancer screening by the year 2018. To achieve the highest level of adherence to colorectal cancer screening, it may… Read More…

A Woman with Progressive Loss of Language

Posted by • January 6th, 2017

The anterior temporal lobe is an area of the brain that is critically involved in object naming and word comprehension. Multiple lines of evidence suggest that the left anterior temporal lobe is specialized for word comprehension (recognition), whereas the right anterior temporal lobe may serve a similar function for objects and faces.   Clinical Pearl • What… Read More…

Zika Virus Infection in Pregnant Women in Rio de Janeiro

Posted by • December 15th, 2016

Zika virus (ZIKV) is a flavivirus that was recently introduced into Brazil. Brasil et al. enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for ZIKV by reverse-transcriptase–polymerase-chain-reaction assays. The authors followed women prospectively to obtain data on pregnancy and infant outcomes. This final… Read More…

Dupilumab versus Placebo in Atopic Dermatitis

Posted by • December 15th, 2016

For patients with moderate-to-severe atopic dermatitis, topical therapies have limited efficacy, and systemic treatments are associated with substantial toxic effects. Thus, there is an unmet need for effective and safe long-term medications for these patients. Simpson et al. reported the results of two phase 3 trials of dupilumab monotherapy (SOLO 1 and SOLO 2) in… Read More…

Stents or Bypass Surgery for Left Main Coronary Artery Disease

Posted by • December 8th, 2016

EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) was an international, open-label, multicenter randomized trial that compared everolimus-eluting stents with coronary-artery bypass grafting (CABG) in patients with left main coronary artery disease. A new Original Article explains how at 3 years, PCI was noninferior to CABG with respect… Read More…

A Woman with Leukocytosis

Posted by • December 8th, 2016

Primary causes of neutrophilia encompass benign, congenital, and familial syndromes. Another category of primary neutrophilias includes those associated with clonal bone marrow diseases. An 86-year-old woman was seen at the hospital because of fatigue, night sweats, leukocytosis, and splenomegaly. Review of the peripheral-blood smear revealed neutrophilia without dysplastic features, immature forms, or monocytosis. A diagnostic… Read More…

Postpartum Depression

Posted by • December 1st, 2016

Untreated postpartum depression is common affects the health of the woman, infant, and family. Pregnant women should receive information about the signs and symptoms of postpartum depression and its effects. Treatment depends on the severity of symptoms and the level of functional impairment and can include social support, psychological therapy, and pharmacotherapy (generally an SSRI… Read More…

Niraparib Maintenance Therapy in Ovarian Cancer

Posted by • December 1st, 2016

Ovarian cancer is a leading cause of death from gynecologic cancers worldwide. A randomized, placebo-controlled, phase 3 trial conducted by Mirza et al. evaluated the efficacy and safety of niraparib versus placebo as maintenance treatment in a broad population of patients with platinum-sensitive, recurrent ovarian cancer. Among these patients, the use of niraparib, a PARP… Read More…

Von Willebrand’s Disease

Posted by • November 24th, 2016

Von Willebrand’s disease is an inherited bleeding disorder characterized by defective platelet adhesion and aggregation. It is the most common inherited bleeding disorder and is generally transmitted as an autosomal dominant trait. It is mainly associated with mucosal bleeding and excessive bleeding after trauma or surgery. A variety of effective treatments are available and research… Read More…

A Man with Acute Liver Injury

Posted by • November 24th, 2016

HEV infection is uncommon in the United States, although 20% of the population has antibodies to HEV. The diagnosis should be considered in patients who present with acute hepatitis after returning from a trip to an area in which HEV is endemic. In a new Case Record article, a 50-year-old man from India with a… Read More…