Posts in the ‘Physicians-In-Training’ Category

The posts below are excerpted from the NEJM Resident e-Bulletin, a free weekly email of teaching topics. Including the content here in Now@NEJM enables you to have a conversation or ask questions about clinical points that interest you. To receive the email version, register as a student or resident on NEJM.org.

Hepatitis C Virus Infection

Posted by Sara Fazio • May 17th, 2013

Only 20 years after the discovery of the hepatitis C virus, a cure is now likely for most people with chronic infection. The latest review in our Drug Therapy series considers current therapy and the present landscape of drug development for hepatitis C. The hepatitis C virus (HCV) carries a substantial disease burden, not only… Read More…

Fever and Altered Mental Status

Posted by Sara Fazio • May 17th, 2013

In the latest Case Record of the Massachusetts General Hospital, 76-year-old man with chronic renal disease was admitted to this hospital because of fever, worsening renal function, and confusion. Brain imaging revealed a small amount of material with restricted diffusion layering in the occipital horns of the lateral ventricles. Typical bacterial organisms that commonly cause… Read More…

Vaginal Bleeding

Posted by Sara Fazio • May 10th, 2013

In the latest Case Record of the Massachusetts General Hospital, a 70-year-old woman was seen in this hospital because of vaginal bleeding. An endometrial-biopsy specimen showed a poorly differentiated malignant neoplasm that was suggestive of mixed müllerian tumor (carcinosarcoma). A diagnostic and therapeutic procedure was performed. The underlying cause of abnormal vaginal bleeding is age-dependent…. Read More…

Enteropathogens in Returning Travelers

Posted by Sara Fazio • May 10th, 2013

Chronic gastrointestinal illness sometimes develops after international travel. The latest review article in our Current Concepts series covers the diagnosis of the major enteropathogens and provides recommendations for treatment. In a recent study that analyzed data from the GeoSentinel Surveillance Network (which consists of 42 specialized travel or tropical-medicine sites located around the world) on… Read More…

In the Thick of It

Posted by Sara Fazio • May 3rd, 2013

In our latest Clinical Problem-Solving article, a 52-year-old man presented to the emergency department with an acute onset of palpitations and chest pressure. He had felt well until 2 days earlier, when epigastric burning, fatigue, weakness, and emesis had developed. The presence of a delta wave together with a short PR interval suggests the presence… Read More…

Injuries

Posted by Sara Fazio • May 3rd, 2013

Injuries, whether intentional or unintentional, account for a substantial burden on the health care system. The latest article in our new Global Health series describes the magnitude of the problem worldwide, enumerates ongoing efforts to prevent injuries, and summarizes systems that need to be in place to care for the injured. In 2010, there were… Read More…

A 6-Year-Old Girl with Bone and Joint Pain

Posted by Sara Fazio • April 26th, 2013

In the latest Case Record of the Massachusetts General Hospital, a 6-year-old girl was admitted to this hospital because of bone and joint pain for 1 year and recent onset of fever and abdominal distention. Imaging revealed a mass in the abdominal and pelvic region and lesions in the liver, kidneys, and multiple bones. A… Read More…

Chronic Pruritus

Posted by Sara Fazio • April 26th, 2013

Chronic pruritus requires careful evaluation for primary dermatologic or systemic causes. In addition to treatment of the underlying cause, when identified, various topical and systemic therapies may be used, although supporting data from randomized trials are scarce. The latest article in our Clinical Practice series comes from Dr. Gil Yosipovitch of Wake Forest University Baptist… Read More…

18-Year-Old with Respiratory Failure

Posted by Sara Fazio • April 19th, 2013

In the latest Case Record of the Massachusetts General Hospital, an 18-year-old woman was admitted to this hospital because of pulmonary infiltrates and respiratory failure. Three weeks before admission, fever, cough, and painful pharyngitis developed. Diagnostic tests were performed. In a young patient without comorbid illnesses, there are many potential infectious causes of pneumonia. The… Read More…

Belimumab for SLE

Posted by Sara Fazio • April 19th, 2013

In the latest review article in our Clinical Therapeutics series, a 20-year-old woman with SLE presents with disease flares and receives belimumab, a monoclonal antibody that binds to B-cell activating factor, inhibiting B-cell stimulation. Belimumab is considered for patients who do not have a response or have adverse effects with first-line therapies. Clinical Pearls • What… Read More…