Our latest Clinical Decisions presents the case of a 25-year-old woman with incidentally identified hepatitis C virus infection. Three possible treatment options, any of which could be considered correct, are provided. We asked you to vote for one and welcomed comments about your choice. A broad selection of these comments are now available for your viewing. Visit NEJM.org to access earlier Clinical Decisions on the care of an unresponsive patient; the management of skin and soft-tissue infection, Type 2 diabetes, and stable coronary disease; and the treatment of mild persistent asthma.