Posts Tagged ‘atopic dermatitis’

Dupilumab versus Placebo in Atopic Dermatitis

Posted by • December 15th, 2016

For patients with moderate-to-severe atopic dermatitis, topical therapies have limited efficacy, and systemic treatments are associated with substantial toxic effects. Thus, there is an unmet need for effective and safe long-term medications for these patients. Simpson et al. reported the results of two phase 3 trials of dupilumab monotherapy (SOLO 1 and SOLO 2) in… Read More…

Dupilumab as a Treatment for Atopic Dermatitis

Posted by • July 9th, 2014

For thousands of years, our knowledge of medications has largely been based on trial and error: we haphazardly used substances and learned from the effects. Within the last half a century, however, rational drug design slowly took to the forefront as scientific discoveries improved our understanding of the underlying pathogenesis of diseases. While there have… Read More…

Hand Eczema

Posted by • November 7th, 2012

The latest article in our Clinical Practice review series, Hand Eczema, comes from Dr. Pieter-Jan Coenraads at the University Medical Center Groningen in the Netherlands. Hand eczema, also called hand dermatitis, is an inflammation of the skin of the hands; some persons with hand eczema may also have foot eczema. Typical clinical signs are redness, infiltration… Read More…

Fever and Rash

Posted by • May 10th, 2012

In the latest Case Record of the Massachusetts General Hospital, a 43-year-old woman with a history of atopic dermatitis was admitted to the hospital because of fever and a generalized painful, pruritic rash involving the entire body. Examination revealed vesicles, pustules, and erosions with scalloped borders. A diagnostic test result was received. The development of cutaneous pain in… Read More…