August 4th, 2010
Three Questions about Ticagrelor: Part 2 — Mori Krantz
Sanjay Kaul, MD
PLATO is one of the most impressive trials in recent years, demonstrating substantial benefits for ticagrelor over clopidogrel in a wide population of ACS patients. However, patients enrolled in the US were found to have no benefit from ticagrelor, and experts have been unable to agree on a cause. Possible factors could include much higher doses […]
August 4th, 2010
Research Suggests Possible New Early Strategies for HCM
Sanjay Kaul, MD
CardioExchange welcomes Carolyn Ho to discuss her study in the New England Journal of Medicine, which looked at myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy (HCM). Her team found that levels of serum C-terminal propeptide of type I procollagen (PICP) were higher in mutation carriers without LVH and in patients with HCM than […]
August 3rd, 2010
Vitamin B Trial Finds No Clinically Significant Benefit
Larry Husten, PHD
The VITATOPS (The VITAmins TO Prevent Stroke) Trial randomized 8164 patients with recent stroke or TIA to either placebo or B vitamins. After a median followup of 3.4 years, the primary endpoint — the combined incidence of stroke, MI, or vascular death — occurred in 616 patients in the B vitamin group and 678 in the placebo […]
August 3rd, 2010
Three Questions about Ticagrelor: Part 1 — Sanjay Kaul
Sanjay Kaul, MD
PLATO is one of the most impressive trials in recent years, demonstrating substantial benefits for ticagrelor over clopidogrel in a wide population of ACS patients. However, patients enrolled in the US showed no benefit from ticagrelor, and experts have been unable to agree on a cause. Possible factors could include much higher doses of aspirin used […]
August 3rd, 2010
Building on Your Success
Harlan M. Krumholz, MD, SM
Welcome to the remodeled CardioExchange: We hope you like our new look! In our efforts to develop a website that promotes learning and discussion about our rapidly evolving field, we’ve been listening and learning. We have many new features. Some of the most prominent are: You can now see all of the activity on the site […]
August 2nd, 2010
Framingham: Cardiac Function Linked to Brain Aging
Larry Husten, PHD
Brain age is closely associated with cardiac function, according to a new report in Circulation from the Framingham Heart Study. Angela Jefferson and colleagues collected brain MRI, cardiac MRI, neuropsychological, and laboratory data on 1504 participants in the Framingham Offspring Cohort and found a significant association between neuropsychological and brain MRI variables and cardiac index […]
August 2nd, 2010
When in Rome…
John Mandrola, MD, FACC
CardioExchange welcomes this guest post reprinted with permission from Dr. John M, a blog by private-practice electrophysiologist and CardioExchange member, Dr. John Mandrola. In the quiet of the exam room, the patient’s cell phone obnoxiously chimes to life. “Hold on a minute Doc, I’ve been expecting this text.” You think, but dare not say, “You are […]