NEJM — Recent Cardiology Articles- In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia May 25, 2026The authors report reductions in PCSK9 and LDL cholesterol levels and no dose-limiting toxic effects in persons with hypercholesterolemia treated with VERVE-102, a base editor targeting PCSK9.
- Double Take: Cardiovascular Risk Factors — Hypertension May 20, 2026This Double Take video outlines the five risk factors for cardiovascular disease and reviews strategies for blood-pressure control to reduce morbidity and mortality.
- Endovascular Therapy for Medium-Vessel Occlusion Stroke — Narrowing the Target Population May 14, 2026One way to classify acute ischemic stroke is by the anatomy of vessel occlusion. Initial randomized trials of endovascular thrombectomy focused on large-vessel occlusions.1-5 These proximal occlusions of the intracranial carotid artery or the stem of the middle cerebral artery (MCA) represent the most severe form of anterior...
- Central Retinal-Vein Occlusion May 14, 2026A 65-year-old woman with cardiovascular risk factors presented with a 14-hour history of painless, worsening, blurry vision in the right eye (visual acuity, 20/400). Funduscopy showed diffuse retinal hemorrhages and venous dilatation.
- Endovascular Treatment of Medium-Vessel-Occlusion Strokes May 14, 2026Among patients with stroke due to medium-vessel occlusion, thrombectomy led to functional independence at 90 days (in 58.6% of patients, vs. 46.6% with medical management) but also to a higher risk of intracranial hemorrhage.
- In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia May 25, 2026
