January 26th, 2015
Selections from Richard Lehman’s Literature Review: January 26th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include dietary sodium content, mortality, and CVD risk in older adults, the ROX CONTROL HTN study, and more.
June 24th, 2013
Selections from Richard Lehman’s Literature Review: June 24th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include time to treatment with IV tPA and outcome from acute ischemic stroke, rapid BP lowering in those with acute intracerebral hemorrhage, and more.
NEJM — Recent Cardiology Articles- Obstructive Hypertrophic Cardiomyopathy August 1, 2026A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricular walls during systole.
- Pulsatile Liver in Severe Tricuspid Regurgitation July 30, 2026A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).
- Platelet-Activating Anti–Platelet Factor 4 Disorders July 30, 2026This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies.
- Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy July 23, 2026In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo.
- Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD July 22, 2026In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.
- Obstructive Hypertrophic Cardiomyopathy August 1, 2026