An ongoing dialogue on HIV/AIDS, infectious diseases,
Paul E. Sax, MD
Associate Editor
NEJM Clinician
Biography | Disclosures & Summaries
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FROM NEJM — Recent Infectious Disease Articles- Resolution of PML after Treatment with Virus-Specific T Cells and HCT May 28, 2026Two patients with inborn errors of immunity and progressive multifocal leukoencephalopathy received polyomavirus-specific T cells, followed by allogeneic hematopoietic transplantation with good neurologic outcomes.
- Case 15-2026: A 64-Year-Old Woman with Fatigue, Memory Changes, and Falls May 28, 2026A 64-year-old woman presented with fatigue, memory changes, and falls. MRI of the head revealed numerous hyperintense foci in the white matter on fluid-attenuated inversion recovery images. A diagnosis was made.
- A Major Step toward a Cure for Hepatitis B Infection May 28, 2026The current treatment of chronic hepatitis B infection includes nucleoside or nucleotide analogue (NA) therapy and pegylated interferon. Both of these treatments are effective in suppressing hepatitis B virus (HBV) replication and in reducing the risk of cirrhosis and hepatocellular carcinoma.1 However, these treatments do not eradicate HBV,...
- Getting Serious about Tickborne Diseases — Shifting Research Priorities May 28, 2026Research on Lyme disease has emphasized clinical disease and pathogen microbiology rather than the root cause: the infected tick vectors in the environment, which remain uncontrolled.
- Leishmaniasis May 28, 2026Leishmaniases are clinically distinct parasitic diseases transmitted by infected sand flies. Laboratory diagnosis has shifted to molecular methods. Treatment choices are limited; two vaccines are being tested.
- Resolution of PML after Treatment with Virus-Specific T Cells and HCT May 28, 2026