March 31st, 2014
Novartis Trial Was Stopped Early Because of a Significant Drop in Cardiovascular Mortality
Larry Husten, PHD
The largest-ever trial in heart failure was stopped early because of a highly statistically significant reduction in cardiovascular mortality, according to one of the trial’s two primary investigators. Earlier today I reported that the PARADIGM-HF trial testing LCZ696, a novel, first-in-class Angiotensin Receptor Neprilysin Inhibitor (ARNI), had been stopped early because the trial had demonstrated a significant reduction in the […]
March 31st, 2014
Master of All Trades
Saurav Chatterjee, MD
Saurav Chatterjee reflects on the growing demands of fellows embarking on careers in private practice.
March 31st, 2014
Early Success for Novel Novartis Heart Failure Drug
Larry Husten, PHD
A large clinical trial testing a novel compound from Novartis for chronic heart failure has been stopped early for efficacy. In a press release Novartis said the Data Monitoring Committee had recommended early closure of the PARADIGM-HF trial because the trial had demonstrated a significant reduction in the combined primary endpoint of cardiovascular death and heart failure hospitalization. PARADIGM-HF randomized patients with heart […]
March 31st, 2014
Are We Equipped to Make a CHOICE Between TAVR Devices?
E Murat Tuzcu, MD
E. Murat Tuzcu offers his perspective on the CHOICE trial comparing the CoreValve and Edwards Sapien XT devices for transcatheter aortic valve replacement.
March 31st, 2014
Aspirin and Clonidine Fail to Help Surgery Patients
Larry Husten, PHD
Myocardial infarction (MI) is among the most common and serious side effects of noncardiac surgery. An effective regimen to minimize this risk has been the subject of considerable debate in recent years. The controversy was recently exacerbated because the recommendation to use beta-blockers in this setting was based on research which has now been discredited. Substantial […]
March 30th, 2014
High-Sensitivity Troponin Test Could Identify Low-Risk Chest Pain Patients in the ED
Larry Husten, PHD
Approximately 15-20 million people in Europe and the United States go to the emergency department every year with chest pain. Many can be discharged early if they are not having an acute coronary syndrome. A large, new, single-center observational study, presented at the American College of Cardiology meeting in Washington, DC and published simultaneously in the Journal […]
March 30th, 2014
Stage Set for Phase IV Trials of PCSK9 Inhibition
Seth Shay Martin, MD
Seth Martin, a fellow blogging at ACC.14, discusses some exciting developments taking place at the conference.
March 30th, 2014
Taking Patient-Centeredness to the Next Level at ACC.14
Kumar Dharmarajan, MD MBA
A fellow discusses an interesting lecture approach at ACC.14.
March 30th, 2014
Are Digital Conferences the Way of the Future?
Saurav Chatterjee, MD
A fellow reflects on how technology may impact meetings in the years to come.
March 30th, 2014
Ideas Lost, But Not Stolen
Seth Shay Martin, MD
A fellow blogs about an unfortunate experience at ACC.14 – and how it it made him realize the value of his work.