January 6th, 2014
Selections from Richard Lehman’s Literature Review: January 6th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include the NAVIGATOR study, trials of stents, mitral valve repair vs. replacement, and more.
NEJM — Recent Cardiology Articles- Pulsatile Liver in Severe Tricuspid Regurgitation July 25, 2026A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video).
- Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy July 23, 2026In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo.
- Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD July 22, 2026In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels.
- Descending Thoracic Aortic Aneurysm July 16, 2026A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart.
- Balancing the Scales — Extended DAPT in Coronary Artery Disease July 16, 2026The appropriate duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) has remained the subject of a central debate in cardiovascular medicine. DAPT is intended to mitigate ischemic risk, but its maintenance warrants balancing the benefit against the concomitant risk of hemorrhage.1 Consequently, determining the appropriate...
- Pulsatile Liver in Severe Tricuspid Regurgitation July 25, 2026