January 6th, 2014
Selections from Richard Lehman’s Literature Review: January 6th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include the NAVIGATOR study, trials of stents, mitral valve repair vs. replacement, and more.
NEJM — Recent Cardiology Articles- Complete Revascularization Guided by Functional Coronary Angiography in STEMI September 10, 2026Among patients with ST-segment elevation myocardial infarction and multivessel disease, physiology-guided angiography led to a lower risk of major cardiovascular events than conventional angiography-guided treatment.
- Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials September 9, 2026In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common.
- Immediate Ambulatory Electrocardiographic Monitoring in Syncope August 31, 2026Among patients with syncope that remained unexplained after evaluation in the ED, immediate initiation of 14-day ECG monitoring did not result in significantly fewer patient-reported syncope episodes at 1 year than standard care.
- Catheter-Directed Thrombolysis in Intermediate-High–Risk Pulmonary Embolism August 31, 2026Catheter-directed thrombolysis led to a lower risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse at 7 days than anticoagulation alone in intermediate-high–risk acute pulmonary embolism.
- Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation August 30, 2026In patients with severe aortic stenosis and coronary artery disease, a strategy of transcatheter aortic-valve implantation before percutaneous coronary intervention was noninferior to PCI before TAVI for major clinical events at 1 year.
- Complete Revascularization Guided by Functional Coronary Angiography in STEMI September 10, 2026