January 6th, 2014
Selections from Richard Lehman’s Literature Review: January 6th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include the NAVIGATOR study, trials of stents, mitral valve repair vs. replacement, and more.
NEJM — Recent Cardiology Articles- The Broader Dangers of Abandoning SGM Health Research August 15, 2026When research is defunded not for scientific reasons but because it has become politically inconvenient, the ensuing damage is wide ranging, affecting far more than the disfavored topics and populations.
- In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia August 13, 2026The authors report reductions in PCSK9 and LDL cholesterol levels and no dose-limiting toxic effects in persons with hypercholesterolemia treated with VERVE-102, a base editor targeting PCSK9.
- A New Approach to Lowering LDL Cholesterol August 13, 2026The pioneering work of Vafai and colleagues, reported in this issue of the Journal,1 paves the way for a new type of low-density lipoprotein (LDL) cholesterol–lowering therapy called VERVE-102: a therapy that appears to lower LDL cholesterol levels enough to reduce the risk of atherosclerotic cardiovascular...
- Last Man Running August 13, 2026As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.
- Mineralocorticoid Receptor Antagonism — FINDing Another Benefit August 6, 2026Aldosterone plays a critical role in the homeostasis of blood pressure and volume by engaging mineralocorticoid receptors in the kidneys, heart, and other organs.1 However, overactivation of mineralocorticoid receptors contributes to the pathogenesis of chronic kidney disease (CKD) and heart failure, in part by causing inflammation and fibrosis....
- The Broader Dangers of Abandoning SGM Health Research August 15, 2026