January 6th, 2014
Selections from Richard Lehman’s Literature Review: January 6th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include the NAVIGATOR study, trials of stents, mitral valve repair vs. replacement, and more.
NEJM — Recent Cardiology Articles- Thromboprophylaxis for Atrial Fibrillation in Patients with Drug-Eluting Stents February 12, 2026Stroke prevention is one of the pillars of treatment for patients with atrial fibrillation, and oral anticoagulation with a direct oral anticoagulant (DOAC) is now the preferred option for thromboprophylaxis.1 Nevertheless, patients with atrial fibrillation commonly have coexistent vascular disease, so they may present with an acute...
- Adenoviral Inciting Antigen and Somatic Hypermutation in VITT February 12, 2026VITT is caused by a somatic hypermutation of an anti–adenovirus pVII antibody that generates more avid binding of platelet factor 4 than of adenovirus pVII, its original target, which results in platelet activation.
- Case 5-2026: An 18-Year-Old Woman with Headache and Hypertension February 12, 2026An 18-year-old woman with chronic headaches was admitted to the pediatric intensive care unit for a hypertensive emergency. The potassium level was 2.0 mmol per liter. A diagnosis was made.
- Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents February 12, 2026In patients with atrial fibrillation and a drug-eluting stent placed at least 1 year earlier, monotherapy with a non–vitamin K antagonist oral anticoagulant was noninferior to combination therapy with clopidogrel for net adverse clinical events.
- LVAD February 5, 2026When a man ends up in the ED after having severed the driveline of his left ventricular assist device, the medical student on his team learns that sometimes a life saved is not the life the patient wants to live.
- Thromboprophylaxis for Atrial Fibrillation in Patients with Drug-Eluting Stents February 12, 2026