An ongoing dialogue on HIV/AIDS, infectious diseases,
Paul E. Sax, MD
Associate Editor
NEJM Clinician
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FROM NEJM — Recent Infectious Disease Articles- History of Medicine: Smallpox at the Siege of Boston, November 1775–March 1776 December 11, 2025Smallpox played a pivotal role throughout the American Revolution, but the record remains ambiguous about whether British officers weaponized refugees to sow pestilence in the Continental Army.
- Current and Emerging Approaches to Evaluating Influenza Vaccine Performance December 11, 2025Randomized, placebo-controlled trials are widely accepted as the scientific reference standard to determine a causal association between an intervention and an outcome. They are pivotal for product licensure. Although such trials establish safety and efficacy with the assumption that bias has been eliminated, limitations remain. For vaccines, establishing the duration...
- High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults December 11, 2025Among adults 65 years of age or older, a high-dose influenza vaccine did not result in a significantly lower incidence of hospitalization for influenza or pneumonia than a standard-dose vaccine.
- High-Dose Influenza Vaccine to Reduce Hospitalizations December 11, 2025In adults 65 to 79 years of age, there appeared to be fewer hospitalizations for influenza or pneumonia with high-dose influenza vaccine than with the standard dose, with a similar incidence of serious adverse events.
- Brief Report: Prime Editing for p47phox-Deficient Chronic Granulomatous Disease December 7, 2025In this study, gene editing with a prime editor was used to treat two persons with chronic granulomatous disease caused by a small deletion in the gene NCF1.
- History of Medicine: Smallpox at the Siege of Boston, November 1775–March 1776 December 11, 2025